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Health effects of particles from motor engine exhaust and ambient air pollution - a european collaborative project

Objective

In this application, for the first time, particulate matter (PM) will be collected from sites used in epidemiology (in addition to fresh diesel and gasoline PM) and extensively characterised physico-chemically prior to evaluation of bioactivity in in-vitro and in-vivo animals models. This unique approach will provide novel information of the oxidative and inflammatory reactivity of PM across Europe. Healthy controls, asthma and COPD patients are exposed to diesel, gasoline or selected ambient PM by inhalation/local bronchial instillation. Calculations of physico-chemical composition/source/ toxicity-health relationships thereby become feasible. The novel approach to link epidemology, toxicology and controlled human exposures will facilities a synergistic increase in the understanding of the adverse effects of PM. Moreover, it should help identify those components of PM which are of most importance for regulatory decision making within Europe.

Call for proposal

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Coordinator

UNIVERSITY OF UMEAA
Address
Universitetsomraadet
901 87 Umeaa
Sweden

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Participants (8)

Head of the Unit of Foodborne Zoonoses and Veterinary Epidemiology
Italy
Address
Viale Regina Elena 299
00161 Rome

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KING'S COLLEGE LONDON
United Kingdom
Address
Strand
WC2R 2LS London

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LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH
Germany
Address
Geschwister-scholl-platz 1
80539 Muenchen

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NATIONAL INSTITUTE OF PUBLIC HEALTH AND ENVIRONMENT
Netherlands
Address
9,antonie Van Leeuwenhoeklaan 9
3720 BA Bilthoven

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UNIVERSITY OF SOUTHAMPTON
United Kingdom
Address
University Road, Highfield
Southampton

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UNIVERSITY OF ULM
Germany
Address
Helmholtzstrasse, 22
89081 Ulm

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University of Edinburgh
United Kingdom
Address
Old College South Bridge
EH1 1HN Edinburgh

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WISE & MUNRO LEARNING RESEARCH
Netherlands
Address
8,azaleastraat 85
2565 CD Den Haag

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