Health effects of particles from motor engine exhaust and ambient air pollution - a european collaborative project

Objective

In this application, for the first time, particulate matter (PM) will be collected from sites used in epidemiology (in addition to fresh diesel and gasoline PM) and extensively characterised physico-chemically prior to evaluation of bioactivity in in-vitro and in-vivo animals models. This unique approach will provide novel information of the oxidative and inflammatory reactivity of PM across Europe. Healthy controls, asthma and COPD patients are exposed to diesel, gasoline or selected ambient PM by inhalation/local bronchial instillation. Calculations of physico-chemical composition/source/ toxicity-health relationships thereby become feasible. The novel approach to link epidemology, toxicology and controlled human exposures will facilities a synergistic increase in the understanding of the adverse effects of PM. Moreover, it should help identify those components of PM which are of most importance for regulatory decision making within Europe.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-4. - Key action Environment and Health

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF UMEAA

Address

Universitetsomraadet
901 87 Umeaa
Sweden

Participants (8)

Head of the Unit of Foodborne Zoonoses and Veterinary Epidemiology

Italy

Address

Viale Regina Elena 299
00161 Rome

KING'S COLLEGE LONDON

United Kingdom

Address

Strand
WC2R 2LS London

LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH

Germany

Address

Geschwister-scholl-platz 1
80539 Muenchen

NATIONAL INSTITUTE OF PUBLIC HEALTH AND ENVIRONMENT

Netherlands

Address

9,Antonie Van Leeuwenhoeklaan 9
3720 BA Bilthoven

UNIVERSITY OF SOUTHAMPTON

United Kingdom

Address

University Road, Highfield
Southampton

UNIVERSITY OF ULM

Germany

Address

Helmholtzstrasse, 22
89081 Ulm

University of Edinburgh

United Kingdom

Address

Old College South Bridge
EH1 1HN Edinburgh

WISE & MUNRO LEARNING RESEARCH

Netherlands

Address

8,Azaleastraat 85
2565 CD Den Haag