Objective
In this application, for the first time, particulate matter (PM) will be collected from sites used in epidemiology (in addition to fresh diesel and gasoline PM) and extensively characterised physico-chemically prior to evaluation of bioactivity in in-vitro and in-vivo animals models. This unique approach will provide novel information of the oxidative and inflammatory reactivity of PM across Europe. Healthy controls, asthma and COPD patients are exposed to diesel, gasoline or selected ambient PM by inhalation/local bronchial instillation. Calculations of physico-chemical composition/source/ toxicity-health relationships thereby become feasible. The novel approach to link epidemology, toxicology and controlled human exposures will facilities a synergistic increase in the understanding of the adverse effects of PM. Moreover, it should help identify those components of PM which are of most importance for regulatory decision making within Europe.
Fields of science
- engineering and technologyenvironmental engineeringenergy and fuelsliquid fuels
- medical and health sciencesclinical medicinepneumologyasthma
- engineering and technologyenvironmental engineeringair pollution engineering
- natural sciencesearth and related environmental sciencesenvironmental sciencespollution
- medical and health sciencesbasic medicinetoxicology
Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
901 87 Umeaa
Sweden
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Participants (8)
00161 Rome
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WC2R 2LS London
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80539 Muenchen
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3720 BA Bilthoven
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Southampton
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89081 Ulm
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EH1 1HN Edinburgh
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2565 CD Den Haag
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