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Content archived on 2024-05-24

Mechanisms of toxicity of asbestos substitute mineral fibres: new approaches to hazard and risk assessment.

Objective

This project aims to support the hazard and risk assessment of asbestos substitute fibres. The potential for induction of inflammatory changes, oxidative stress, immunotoxicity and genotoxicity will be eximined for three substitute fibres (glass fibres, rock wool, wollastonite) and compared to that of amosite asbestos. Novel cell culture or whole animal systems will be employed to obtained information on the molecular mechanisms and the dose-response relationships governing the induction of the above toxic effects for use in human population studies. These biomarkers of exposure and early effects for use in human population studies. These biomarkers will be applied, together with already existing biomarkers, in biomonitoring studies of cohorts of fibre workers.

Call for proposal

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Coordinator

NATIONAL HELLENIC RESEARCH FOUNDATION
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Vassileos Constantinou Avenue 48
ATHENS
Greece

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Participants (6)