Skip to main content

Mechanisms of toxicity of asbestos substitute mineral fibres: new approaches to hazard and risk assessment.

Objective

This project aims to support the hazard and risk assessment of asbestos substitute fibres. The potential for induction of inflammatory changes, oxidative stress, immunotoxicity and genotoxicity will be eximined for three substitute fibres (glass fibres, rock wool, wollastonite) and compared to that of amosite asbestos. Novel cell culture or whole animal systems will be employed to obtained information on the molecular mechanisms and the dose-response relationships governing the induction of the above toxic effects for use in human population studies. These biomarkers of exposure and early effects for use in human population studies. These biomarkers will be applied, together with already existing biomarkers, in biomonitoring studies of cohorts of fibre workers.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

NATIONAL HELLENIC RESEARCH FOUNDATION
Address
Vassileos Constantinou Avenue 48
Athens
Greece

Participants (6)

FODOR JOZSEF NATIONAL PUBLIC HEALTH CENTRE
Hungary
Address
Nagyvarad Ter 2
1450 Budapest
GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH
Germany
Address
Ingolstaedter Landstrasse 1
85764 Neuherberg
INSTITUTE OF MOLECULAR BIOLOGY - BULGARIAN ACADEMY OF SCIENCES
Bulgaria
Address
21,Bld Acad. Bonchev 21
1113 Sofia
INSTITUTE OF PREVENTIVE AND CLINICAL MEDICINE
Slovakia
Address
14,Limbova 14
833 01 Bratislava
PURKYNJE MILITARY MEDICAL ACADEMY
Czechia
Address
Trebesska 1575
500 01 Hradec Kralove
THE ROBERT GORDON UNIVERSITY
United Kingdom
Address
Schoolhill
Aberdeen