Objective
This project will evaluate the hypothesis that Paths are the major source ofgenotoxic activities of organic mixtures associated with air pollution. Such exposures result in exogenous DNA damage but the importance of endogenous damages unknown. Exposure of 4 populations exposed to Paths will be measured and lifestyle factors determined. Exogenous exposure will be measured by determination of adducts, protein induction, and gene expression, and endogenous damage by measurement of oxidative DNA modification. Effect will be monitored by determination of chromosome aberration, and susceptibility by genotyping a wide variety of enzymes involved in carcinogen metabolism. Model in vitro cell systems will be proposed for studying the impact of Paths in complex mixtures of different air pollution origin. The project will define which biomarkers should be used for risk assessment of environmental exposure to Paths.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- engineering and technology environmental engineering air pollution engineering
- natural sciences earth and related environmental sciences environmental sciences pollution
- natural sciences biological sciences genetics chromosomes
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LE1 9HN Leicester
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.