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Effects of pahs in environmental pollution on exogenous and endogenous dna damage

Objective

This project will evaluate the hypothesis that Paths are the major source ofgenotoxic activities of organic mixtures associated with air pollution. Such exposures result in exogenous DNA damage but the importance of endogenous damages unknown. Exposure of 4 populations exposed to Paths will be measured and lifestyle factors determined. Exogenous exposure will be measured by determination of adducts, protein induction, and gene expression, and endogenous damage by measurement of oxidative DNA modification. Effect will be monitored by determination of chromosome aberration, and susceptibility by genotyping a wide variety of enzymes involved in carcinogen metabolism. Model in vitro cell systems will be proposed for studying the impact of Paths in complex mixtures of different air pollution origin. The project will define which biomarkers should be used for risk assessment of environmental exposure to Paths.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

MEDICAL RESEARCH COUNCIL
Address
Lancaster Road University Of Leicester Hodgkin Bui
LE1 9HN Leicester
United Kingdom

Participants (6)

CANCER RESEARCH INSTITUTE - SLOVAK ACADEMY OF SCIENCES
Slovakia
Address
59,Vlarska 7
833 91 Bratislava
GENETICS RESEARCH INSTITUTE ONLUS
Italy
Address
Strada Della Carita 10
20135 Milano
INSTITUTE OF EXPERIMENTAL MEDICINE - ACADEMY OF SCIENCES OF THE CZECH REPUBLIC
Czechia
Address
Videnska 1083
142 20 Praha 4
NATIONAL CENTRE FOR HYGIENE, MEDICAL ECOLOGY AND NUTRITION
Bulgaria
Address
15,Dimitar Nestorov Boulevard 15
1431 Sofia
THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLEAR PHYSICS
Poland
Address
152,Radzikowskiego 152
31 342 Krakow
UNIVERSITY P.J. SAFARIK
Slovakia
Address
1,Tr.snp 1
040 60 Kosice