Effects of pahs in environmental pollution on exogenous and endogenous dna damage

Objective

This project will evaluate the hypothesis that Paths are the major source ofgenotoxic activities of organic mixtures associated with air pollution. Such exposures result in exogenous DNA damage but the importance of endogenous damages unknown. Exposure of 4 populations exposed to Paths will be measured and lifestyle factors determined. Exogenous exposure will be measured by determination of adducts, protein induction, and gene expression, and endogenous damage by measurement of oxidative DNA modification. Effect will be monitored by determination of chromosome aberration, and susceptibility by genotyping a wide variety of enzymes involved in carcinogen metabolism. Model in vitro cell systems will be proposed for studying the impact of Paths in complex mixtures of different air pollution origin. The project will define which biomarkers should be used for risk assessment of environmental exposure to Paths.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-4. - Key action Environment and Health

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

MEDICAL RESEARCH COUNCIL

Address

Lancaster Road University Of Leicester Hodgkin Bui
LE1 9HN Leicester
United Kingdom

Participants (6)

CANCER RESEARCH INSTITUTE - SLOVAK ACADEMY OF SCIENCES

Slovakia

Address

59,Vlarska 7
833 91 Bratislava

GENETICS RESEARCH INSTITUTE ONLUS

Italy

Address

Strada Della Carita 10
20135 Milano

INSTITUTE OF EXPERIMENTAL MEDICINE - ACADEMY OF SCIENCES OF THE CZECH REPUBLIC

Czechia

Address

Videnska 1083
142 20 Praha 4

NATIONAL CENTRE FOR HYGIENE, MEDICAL ECOLOGY AND NUTRITION

Bulgaria

Address

15,Dimitar Nestorov Boulevard 15
1431 Sofia

THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLEAR PHYSICS

Poland

Address

152,Radzikowskiego 152
31 342 Krakow

UNIVERSITY P.J. SAFARIK

Slovakia

Address

1,Tr.snp 1
040 60 Kosice