Objective Increasing pollution and contamination of the environment with xenobiotics may be linked to the increasing prevalence of allergic diseases throughout Europe. The hypothesis addressed by this proposal is that maternal environmental exposure to xenobiotics during pregnancy triggers intrauterine sensitisation and modulation of placental enzyme and immune function. Resulting unbalanced cytokine production will affect the immunoregulation of the placenta and may initiate an allergic reaction following further exposure in childhood resulting in higher levels of clinical allergy in children postnatal. Extent of placental transfer and fatal uptake of xenobiotics will be measured directly with a human perused placenta model and these data will be correlated with epidemiological information on the development of allergy in maternally exposed children. Fields of science medical and health sciencesclinical medicineobstetricsnatural sciencesearth and related environmental sciencesenvironmental sciencespollutionmedical and health sciencesclinical medicineallergologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-4. - Key action Environment and Health Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY OF BRISTOL Address Horsfield road bristol oncology centre BS2 8ED Bristol United Kingdom See on map EU contribution € 0,00 Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all COMENIUS UNIVERSITY Slovakia EU contribution € 0,00 Address 6,safarikovo nam 6 818 01 Bratislava See on map NATIONAL INSTITUTE FOR RESEARCH AND DEVELOPMENT FOR ENVIRONMENTAL PROTECTION Romania EU contribution € 0,00 Address Spl. independentei 294 - 77703 sector 6 Bucuresti See on map SLOVAK MEDICAL UNIVERSITY Slovakia EU contribution € 0,00 Address Limbova 12 833 03 Bratislava See on map Slovak Postgraduate Academy of Medicine Slovakia EU contribution € 0,00 Address Limbova 14 833 03 Bratislava See on map UNIVERSITAIRE INSTELLING ANTWERPEN - UNIVERSITEIT ANTWERPEN Belgium EU contribution € 0,00 Address Universiteitsplein 1 2610 Wilrijk (antwerpen) See on map UNIVERSITY OF MEDICINE AND PHARMACY 'CAROL DAVILA' IN BUCHAREST Romania EU contribution € 0,00 Address B-dul eroilor sanitari nr. 8 70000 Bucuresti See on map VITO - VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK NV Belgium EU contribution € 0,00 Address Boeretang 200 2400 Mol See on map
