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Placental uptake and transfer of environmental chemicals relating to allergy in childhood years

Objetivo

Increasing pollution and contamination of the environment with xenobiotics may be linked to the increasing prevalence of allergic diseases throughout Europe. The hypothesis addressed by this proposal is that maternal environmental exposure to xenobiotics during pregnancy triggers intrauterine sensitisation and modulation of placental enzyme and immune function. Resulting unbalanced cytokine production will affect the immunoregulation of the placenta and may initiate an allergic reaction following further exposure in childhood resulting in higher levels of clinical allergy in children postnatal. Extent of placental transfer and fatal uptake of xenobiotics will be measured directly with a human perused placenta model and these data will be correlated with epidemiological information on the development of allergy in maternally exposed children.

Convocatoria de propuestas

Data not available

Régimen de financiación

CSC - Cost-sharing contracts

Coordinador

UNIVERSITY OF BRISTOL
Dirección
Horsfield Road Bristol Oncology Centre
BS2 8ED Bristol
United Kingdom

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Participantes (7)

COMENIUS UNIVERSITY
Eslovaquia
Dirección
6,safarikovo Nam 6
818 01 Bratislava

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NATIONAL INSTITUTE FOR RESEARCH AND DEVELOPMENT FOR ENVIRONMENTAL PROTECTION
Rumanía
Dirección
Spl. Independentei 294 - 77703 Sector 6
Bucuresti

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SLOVAK MEDICAL UNIVERSITY
Eslovaquia
Dirección
Limbova 12
833 03 Bratislava

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Slovak Postgraduate Academy of Medicine
Eslovaquia
Dirección
Limbova 14
833 03 Bratislava

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UNIVERSITAIRE INSTELLING ANTWERPEN - UNIVERSITEIT ANTWERPEN
Bélgica
Dirección
Universiteitsplein 1
2610 Wilrijk (Antwerpen)

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UNIVERSITY OF MEDICINE AND PHARMACY 'CAROL DAVILA' IN BUCHAREST
Rumanía
Dirección
B-dul Eroilor Sanitari Nr. 8
70000 Bucuresti

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VITO - VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK NV
Bélgica
Dirección
Boeretang 200
2400 Mol

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