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Placental uptake and transfer of environmental chemicals relating to allergy in childhood years

Objective

Increasing pollution and contamination of the environment with xenobiotics may be linked to the increasing prevalence of allergic diseases throughout Europe. The hypothesis addressed by this proposal is that maternal environmental exposure to xenobiotics during pregnancy triggers intrauterine sensitisation and modulation of placental enzyme and immune function. Resulting unbalanced cytokine production will affect the immunoregulation of the placenta and may initiate an allergic reaction following further exposure in childhood resulting in higher levels of clinical allergy in children postnatal. Extent of placental transfer and fatal uptake of xenobiotics will be measured directly with a human perused placenta model and these data will be correlated with epidemiological information on the development of allergy in maternally exposed children.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF BRISTOL
Address
Horsfield Road Bristol Oncology Centre
BS2 8ED Bristol
United Kingdom

Participants (7)

COMENIUS UNIVERSITY
Slovakia
Address
6,Safarikovo Nam 6
818 01 Bratislava
NATIONAL INSTITUTE FOR RESEARCH AND DEVELOPMENT FOR ENVIRONMENTAL PROTECTION
Romania
Address
Spl. Independentei 294 - 77703 Sector 6
Bucuresti
SLOVAK MEDICAL UNIVERSITY
Slovakia
Address
Limbova 12
833 03 Bratislava
Slovak Postgraduate Academy of Medicine
Slovakia
Address
Limbova 14
833 03 Bratislava
UNIVERSITAIRE INSTELLING ANTWERPEN - UNIVERSITEIT ANTWERPEN
Belgium
Address
Universiteitsplein 1
2610 Wilrijk (Antwerpen)
UNIVERSITY OF MEDICINE AND PHARMACY 'CAROL DAVILA' IN BUCHAREST
Romania
Address
B-dul Eroilor Sanitari Nr. 8
70000 Bucuresti
VITO - VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK NV
Belgium
Address
Boeretang 200
2400 Mol