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Cytogenetic biomarkers and human cancer risk

Objective

The partners have previously shown that a high frequency of chromosomal aberrations (CAs) in peripheral lymphocytes is predictive of increased cancer risk, regardless of smoking or occupational carcinogen exposure. The present multidisciplinary project aims at clarifying the reasons for these findings. Archived cell specimens of subjects earlier examined for cytogenesis biomarkers will be analysed for major genetic polymorphisms suspected to affect chromosome damage. These data will be used to reveal those Polymorphisms that modify the frequency of CAs and of sister chromatic exchanges (SCEs) and the cancer association of CAs. The existing cohorts will be re-examined to identify the types of CAs indicative of cancer risk and to re-evaluate if SCEs predict cancer. Two new European cohorts will be assembled, one to confirm the findings on CAs and SCEs and to study association with major cancer types, and another to see if cancer risk is predicted by lymphocyte micronucleus frequency.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

FINNISH INSTITUTE OF OCCUPATIONAL HEALTH
Address
41 A,topeliuksenkatu 41 A
00250 Helsinki
Finland

Participants (12)

INSTITUTE OF EXPERIMENTAL MEDICINE - ACADEMY OF SCIENCES OF THE CZECH REPUBLIC
Czechia
Address
Videnska 1083
14220 Praha 4
INSTITUTO NAZIONALE PER LA RICERCA SUL CANCRO
Italy
Address
Largo Rosanna Benzi 10
16132 Genova
INTERNATIONAL AGENCY FOR RESEARCH ON CANCER
France
Address
150,Cours Albert Thomas 150
69372 Lyon
JAGIELLONIAN UNIVERSITY
Poland
Address
Kopernika, 25
31501 Krakow
LUND UNIVERSITY
Sweden
Address
University Hospital
221 85 Lund
NATIONAL INSTITUTE OF ONCOLOGY
Hungary
Address
Rath Gyoergy 7-9
1122 Budapest
NATIONAL INSTITUTE OF PUBLIC HEALTH
Czechia
Address
48,Srobarova 48
100 42 Praha 10
RADIATION AND NUCLEAR SAFETY AUTHORITY
Finland
Address
Laippatie 4
00880 Helsinki
STATE HEALTH INSTITUTE
Slovakia
Address
Cesta K. Nemocnici 1
975 56 Banska Bystrica
TELEMARK CENTRAL HOSPITAL
Norway
Address
Ulefossvn.55
3710 Skien
VILNIUS UNIVERSITY
Lithuania
Address
3,Universiteto 3
2734 Vilnius
VRIJE UNIVERSITEIT BRUSSEL
Belgium
Address
Pleinlaan 2
1050 Bruxelles