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Arsenic health risk assessment and molecular epidemiology

Objective

This project studies risks, mechanisms and susceptibility in the aetiology of bladder, skin and kidney cancers in relation to arsenic in drinking water. For 1200 cases and 600 controls, estimates of cumulative dose will be constructed and cancer risks will be estimated in relation to arsenic intake, adjusting for potential confounding by diet, tobacco and occupation. The impact on risk of individual differences in arsenic metabolism, DNA repair and diet will be assessed. For sub groups of the population more detailed analyses of inter-individual differences in speciation, the effect of other nutrients and minerals, and specific polymorphisms will inform models of metabolism. Risk management will be explored for those with the highest continuing exposure. The project will improve quantitative risk assessments, understanding of mechanisms of arsenic toxicity and communication among European researchers in this field.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE
Address
Keppel Street
WC1E 7HT London
United Kingdom

Participants (6)

ENVIRONMENTAL HEALTH CENTER
Romania
Address
Cetatii 23A
3400 Cluj
FODOR JOZSEF NATIONAL PUBLIC HEALTH CENTRE
Hungary
Address
2-6,Gyalli Ut 2-6
1966 Budapest
GERMAN CANCER RESEARCH CENTER
Germany
Address
Im Neuenheimer Feld 280
69120 Heidelberg
KARL-FRANZENS-UNIVERSITAET GRAZ
Austria
Address
Universitaetsplatz 1
8010 Graz
KAROLINSKA INSTITUTE
Sweden
Address
Haelsvaegen 7
141 57 Huddinge
STATE HEALTH INSTITUTE
Slovakia
Address
Cesta K. Nemocnici 1
975 56 Banska Bystrica