Obiettivo
This project studies risks, mechanisms and susceptibility in the aetiology of bladder, skin and kidney cancers in relation to arsenic in drinking water. For 1200 cases and 600 controls, estimates of cumulative dose will be constructed and cancer risks will be estimated in relation to arsenic intake, adjusting for potential confounding by diet, tobacco and occupation. The impact on risk of individual differences in arsenic metabolism, DNA repair and diet will be assessed. For sub groups of the population more detailed analyses of inter-individual differences in speciation, the effect of other nutrients and minerals, and specific polymorphisms will inform models of metabolism. Risk management will be explored for those with the highest continuing exposure. The project will improve quantitative risk assessments, understanding of mechanisms of arsenic toxicity and communication among European researchers in this field.
Campo scientifico
- engineering and technologyenvironmental engineeringwater treatment processesdrinking water treatment processes
- medical and health scienceshealth sciencespublic healthepidemiology
- medical and health scienceshealth sciencesnutrition
- medical and health sciencesclinical medicineoncology
- natural scienceschemical sciencesinorganic chemistrymetalloids
Argomento(i)
Invito a presentare proposte
Data not availableMeccanismo di finanziamento
CSC - Cost-sharing contractsCoordinatore
WC1E 7HT LONDON
Regno Unito