Objective This project studies risks, mechanisms and susceptibility in the aetiology of bladder, skin and kidney cancers in relation to arsenic in drinking water. For 1200 cases and 600 controls, estimates of cumulative dose will be constructed and cancer risks will be estimated in relation to arsenic intake, adjusting for potential confounding by diet, tobacco and occupation. The impact on risk of individual differences in arsenic metabolism, DNA repair and diet will be assessed. For sub groups of the population more detailed analyses of inter-individual differences in speciation, the effect of other nutrients and minerals, and specific polymorphisms will inform models of metabolism. Risk management will be explored for those with the highest continuing exposure. The project will improve quantitative risk assessments, understanding of mechanisms of arsenic toxicity and communication among European researchers in this field. Fields of science engineering and technologyenvironmental engineeringwater treatment processesdrinking water treatment processesmedical and health scienceshealth sciencespublic healthepidemiologymedical and health scienceshealth sciencesnutritionmedical and health sciencesclinical medicineoncologynatural scienceschemical sciencesinorganic chemistrymetalloids Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-4. - Key action Environment and Health Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE Address Keppel street WC1E 7HT London United Kingdom See on map EU contribution € 0,00 Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all ENVIRONMENTAL HEALTH CENTER Romania EU contribution € 0,00 Address Cetatii 23a 3400 Cluj See on map FODOR JOZSEF NATIONAL PUBLIC HEALTH CENTRE Hungary EU contribution € 0,00 Address 2-6,gyalli ut 2-6 1966 Budapest See on map GERMAN CANCER RESEARCH CENTER Germany EU contribution € 0,00 Address Im neuenheimer feld 280 69120 Heidelberg See on map KARL-FRANZENS-UNIVERSITAET GRAZ Austria EU contribution € 0,00 Address Universitaetsplatz 1 8010 Graz See on map KAROLINSKA INSTITUTE Sweden EU contribution € 0,00 Address Haelsvaegen 7 141 57 Huddinge See on map STATE HEALTH INSTITUTE Slovakia EU contribution € 0,00 Address Cesta k. nemocnici 1 975 56 Banska bystrica See on map
