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Air pollution and inflammatory response in myocardial infraction survivors : gene-environment-interactions in high-risk group

Objective

The aim of the proposed study is to determine the association between ambient air pollution and inflammatory responses as markers of early biological effects and to address the individual susceptibility in myocardial infarction survivors. 1200 patients will be repeatedly examined in six European cities (Athens, Augsburg, Barcelona, Helsinki, Rome, Stockholm) within an 8-month period. Ultrafine particle measurements will be conducted and traditional air pollution concentrations will be obtained from the local air hygiene networks. Inflammatory markers and single nucleotide polymorphisrns will be determined in a core laboratories. The data will be analyses with time-series methods. Gene-environment interactions will be analysed for subgroups as mandated by the epidemiological design. The results are relevant for European initiatives to implement targeted prevention strategies on air pollution and to release evidence based guidelines for high-risk populations.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH
Address
Ingolstaedter Landstrase 1
85764 Oberschleissheim
Germany

Participants (6)

KAROLINSKA INSTITUTE
Sweden
Address
Nobels Vaeg, 13
171 77 Stockholm
LOCAL HEALTH AUTHORITY RME
Italy
Address
Via Di Santa Costanza 53J
00198 Roma
NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS
Greece
Address
Mikras Asias Street 75
11527 Athens
NATIONAL PUBLIC HEALTH INSTITUTE
Finland
Address
Neulaniementie 4
70701 Kuopio
UNIVERSITY OF HELSINKI
Finland
Address
Siltavuorenpenger 20 D
00014 Helsinki
University of Ulm
Germany
Address
Albert-einstein-allee 11
89070 Ulm