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Verticillium wilt in tree species; developing essential elements for integrated and innovative management strategies

Objective

Morbidity and mortality due to infections with human cytomegalovirus (HCMV) is considerable in Europe and the rest of the world. Unfortunately, approaches to vaccines so far were associated with safety and efficiency problems. This is largely due to the very limited knowledge of immunological parameters associated with protection from HCMV disease as well information on important viral antigens. The proposed program will use a broadly based approach to the rational design of new vaccine strategies against HCMV. In particular, we will perform a detailed study of the immune responses in women vaccinated with a candidate subunit vaccine and compare it to naturally seropositive women. We will further explore a number of viral envelope lipoproteins for their antigen city and yes structural information to design optimal antigens. Finally, we will use recombinant non-infectious viral particles as a completely new antigen delivery system.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

PLANT RESEARCH INTERNATIONAL B.V.
Address
Droevendaalsesteeg 1
Wageningen
Netherlands

Participants (9)

AGRICULTURAL UNIVERSITY OF ATHENS
Greece
Address
Iera Odos 75
11855 Athens
BENAKI PHYTOPATHOLOGICAL INSTITUTE
Greece
Address
S. Delta Street, 8
14561 Kifisia / Athina
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Finca Alameda Del Obispo S/n
14080 Cordoba
HORTICULTURE RESEARCH INTERNATIONAL
United Kingdom
Address
Wellesbourne
CV35 9EF Warwick
INSTITUTE OF PLANT PROTECTION
Poland
Address
Miczurina, 20
60 318 Poznan
THE SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES
Sweden
Address
1-31,Genetikvägen 1-31
750 07 Uppsala
UNIVERSIDAD DE CORDOBA
Spain
Address
S/n,avenida Menéndez Pidal S/n
14080 Cordoba
UNIVERSITA DEGLI STUDI DI BARI
Italy
Address
Via G. Amendola, 165/A
70126 Bari
WAGENINGEN UNIVERSITY
Netherlands
Address
9,Binnenhaven 9
6709 PD Wageningen