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The role of neurosteroids in healthy ageing: therapeutical perspectives

Objective

Extensive death of nerve cells may no longer be considered as a major event in the process of normal ageing of the nervous system (except in pathological conditions). In addition, the ageing brain and nerves retain sufficient plasticity for regeneration. This means that treating normal age-related dysfunctions of the nervous system, such as memory loss, will become possible. Indeed, research carried out in the laboratories of the partners has shown that age-related memory deficits and abnormalities of myelin sheaths (which isolate nerve fibres) can be reversed by the administration of neurosteroids (steroids which can be locally synthesised in the nervous system). Two complementary therapeutic strategies will be explored:
1) Increasing the local synthesis of neurosteroids by agonists of themitochondrial benzodiazepine receptor;
2) administering selective neurosteroidcompounds.

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Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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80,avenue De Général Leclerc 80
94276 Le Kremlim Bicetre
France

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Participants (5)

BIOLOGICAL RESEARCH CENTRE - HUNGARIAN ACADEMY OF SCIENCES
Hungary
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62,temesvari Krt. 62
6762 Szeged

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CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Av. Doctor Arce 37
28002 Madrid

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THE UNIVERSITY OF MILANO
Italy
Address
Via Balzaretti 9
20133 Milano

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UNIVERSITY OF DUNDEE
United Kingdom
Address
Ninewells Hospital & Medical School
DD1 9SY Dundee

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University of Cambridge
United Kingdom
Address
Madingley Road
CB3 0ES Cambridge

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