Neurones reveal longevity secrets
Research into age-related pathologies is being given high priority on an international level, as life expectancies are continually expanded. Neuronal abnormalities associated with ageing can often lead to memory loss and a number of other symptoms, it was therefore considered crucial to focus research efforts on ways to reverse neuronal damage and cell death. EU project researchers concluded that neurosteroids (steroids synthesised in the brain, spinal cord and peripheral nerves) could indeed be used to treat neuronal age-related ailments. A two-pronged strategy was devised, consisting of systemic steroid administration and/or simulation of local neurosteroid synthesis. The latter alternative involves the activation and stimulation of a key receptor molecule found in the outer membrane of cellular components, termed mitochondria. The receptor is called 'mitochondrial benzodiazepine receptor (MBR)' and aids the transport of cholesterol from the outer to inner membranes of mitochondria; a key step in neurosteroid synthesis. INSERM researchers established that compounds activating MBR can protect neurons and reverse age-related abnormalities. There is a clear need for the discovery of novel efficient MBR ligands, which can induce neurosteroid synthesis and provide long-term protection. This current line of research could prove the starting point towards such developments and as such could warrant further support from the pharmaceutical sector.
