Objective BACKGROUND: Menopause is a milestone in the ageing process in women, and the cessation of secretion of ovarian estrogens after menopause has a major impact on healthy ageing of women and their quality of life. One of the main determinants of the timing of menopause is the efficiency of the use of the primordial follicle stock. AIM: the determination of the role of anti-mullein hormone (AMH), growth and differentiation factor-9 and -9B (GDF9, GDF9B) in primordial follicle loss. OBJECTIVES and EXPECTED RESULTS:(1) the development of large-scale production of AMH and GDF919B and of specific and sensitive assays to determine AMH and GDF9/9B in biological samples;(2) the investigation of the role of AMH and GDF9/9B in early follicular development in women and in mice;(3) the identification of regulated target genes of AMH and GDF9/9B in developing follicles. Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-6. - Key action The Ageing Population and Disabilities Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator ERASMUS UNIVERSITEIT ROTTERDAM Address 50,dr. molewaterplein 50 3015 GE Rotterdam Netherlands See on map EU contribution € 0,00 Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all OXFORD BROOKES UNIVERSITY GB EU contribution € 0,00 Address Gipsy lane OX3 0BP Oxford/headington See on map UNIVERSITY OF HELSINKI Finland EU contribution € 0,00 Address Haartmaninkatu 3 00014 Helsinki See on map UNIVERSITY OF KUOPIO Finland EU contribution € 0,00 Address 2,neulaniementie 2 70211 Kuopio See on map
