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Early development of ovarian follicles - determination of the timing of menopause

Objective

BACKGROUND: Menopause is a milestone in the ageing process in women, and the cessation of secretion of ovarian estrogens after menopause has a major impact on healthy ageing of women and their quality of life. One of the main determinants of the timing of menopause is the efficiency of the use of the primordial follicle stock. AIM: the determination of the role of anti-mullein hormone (AMH), growth and differentiation factor-9 and -9B (GDF9, GDF9B) in primordial follicle loss. OBJECTIVES and EXPECTED RESULTS:
(1) the development of large-scale production of AMH and GDF919B and of specific and sensitive assays to determine AMH and GDF9/9B in biological samples;
(2) the investigation of the role of AMH and GDF9/9B in early follicular development in women and in mice;
(3) the identification of regulated target genes of AMH and GDF9/9B in developing follicles.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

ERASMUS UNIVERSITEIT ROTTERDAM
Address
50,Dr. Molewaterplein 50
3015 GE Rotterdam
Netherlands

Participants (3)

OXFORD BROOKES UNIVERSITY
United Kingdom
Address
Gipsy Lane
OX3 0BP Oxford/headington
UNIVERSITY OF HELSINKI
Finland
Address
Haartmaninkatu 3
00014 Helsinki
UNIVERSITY OF KUOPIO
Finland
Address
2,Neulaniementie 2
70211 Kuopio