Obiettivo BACKGROUND: Menopause is a milestone in the ageing process in women, and the cessation of secretion of ovarian estrogens after menopause has a major impact on healthy ageing of women and their quality of life. One of the main determinants of the timing of menopause is the efficiency of the use of the primordial follicle stock. AIM: the determination of the role of anti-mullein hormone (AMH), growth and differentiation factor-9 and -9B (GDF9, GDF9B) in primordial follicle loss. OBJECTIVES and EXPECTED RESULTS:(1) the development of large-scale production of AMH and GDF919B and of specific and sensitive assays to determine AMH and GDF9/9B in biological samples;(2) the investigation of the role of AMH and GDF9/9B in early follicular development in women and in mice;(3) the identification of regulated target genes of AMH and GDF9/9B in developing follicles. Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-6. - Key action The Ageing Population and Disabilities Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore ERASMUS UNIVERSITEIT ROTTERDAM Contributo UE Nessun dato Indirizzo 50,Dr. Molewaterplein 50 3015 GE ROTTERDAM Paesi Bassi Mostra sulla mappa Costo totale Nessun dato Partecipanti (3) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto OXFORD BROOKES UNIVERSITY Regno Unito Contributo UE Nessun dato Indirizzo Gipsy Lane OX3 0BP OXFORD/HEADINGTON Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF HELSINKI Finlandia Contributo UE Nessun dato Indirizzo Haartmaninkatu 3 00014 HELSINKI Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF KUOPIO Finlandia Contributo UE Nessun dato Indirizzo 2,Neulaniementie 2 70211 KUOPIO Mostra sulla mappa Costo totale Nessun dato