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Neuroreceptor changes in mild cognitive impairment

Objective

This proposal involves the investigation of patients from memory clinic populations with mild cognitive impairment (MCI). Currently, it is impossible to predict who of these patients later will convert into patients with Alzheimer's disease (AD). MCI patients will be compared with subjects from the normal aging population and in some cases with patients with probable AD. By the use of emission tomography techniques, our aim is an as extensive as possible in vivo mapping of neuroreceptor systems in normal aging and in the early phases of dementia, as well as to explore relevant investigational methods for differentiating between patients within these categories. We intend to relate the findings from functional imaging with the clinical measures in terms of emotional disturbances and neuropsychological findings as well within these categories. We intend to relate the findings from functional imaging with the basis of these results, we will settle the diagnostic value of neuroreceptor imaging tools, for an early diagnosis in the elderly patient with memory and/or emotional symptoms and hopefully be able to point at new potential areas for drug development.

Funding Scheme

CON - Coordination of research actions

Coordinator

COPENHAGEN UNIVERSITY HOSPITAL
Address
Blegdamsvej 9
2100 Koepenhagen
Denmark

Participants (3)

KAROLINSKA INSTITUTE
Sweden
Address
Solnavagen 1
171 77 Stockholm
Università degli Studi di Napoli 'Federico II'
Italy
Address
Corso Umberto I 34
80138 Napoli
VRIJE UNIVERSITEIT AMSTERDAM - VERENIGING VOOR CHRISTELIJK WETENSCHAPPELIJK ONDERWIJS
Netherlands
Address
De Boelelaan 1117
1007 MB Amsterdam