Objective
Frailty is emerging as a major characteristic of elderly people. It is characterised by an impending disability and high risk of morbidity and mortality. The relative impact of environment and genetics on frailty is presently unknown. This question will be addressed by assuming that frailty is low in centenarians' children and by comparing couples of cousins 60-80 years old born from discordant sib pairs as for age of death (one centenarian and his/her sib died at relatively young age) with couples of cousins born from concordant sib pairs (both sibs dead at ages which do not differ more than 5 years). In these samples the unbalance of genetic transmission of alleles of genes related to the stress response will be assessed and compared with measures of frailty (motor and cognitive disabilities) expressed as "frailty index". This approach should help defining risk profiles of healthy/unhealthy ageing in the population.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
87036 RENDE
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.