Objective
The major goal of the current application is to identify molecular determinants of healthy ageing and at the same time to understand the pathology involved in certain age-related dysfunctions. To identify new cellular genes, which play a role in explicative senescence of human cells, we will screen for differences in gene and function, and apply genetic screens to identify cDNA with the potential to either induce or abrogate explicative senescence of fibroblasts and endothelial cells. We will also determine the function of the apoptotic apparatus in senescent cells and compare the response of different cell types to apoptotic stimuli, as a function of cellular age. To correlate senescence-associated molecular changes that are identified in vitro with age-related changes occurring in vivo, we will determine the expression and function of selected senescence-associated genes in biopsies derived from
I) healthy donors at different age,
ii) patients suffering from extrinsic ageing and
iii) patients with premature ageing syndromes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
A - 6020 INNSBRUCK
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.