Objective Chronic Obstructive Pulmonary Disease (COPD) is a common cause of disability among elder EU citizens. An important factor compounding disability in COPD is dysfunction of skeletal muscle (both respiratory and locomotor). ENIGMA unites teams working on physiological, metabolic and structural mechanisms of muscle dysfunction in COPD to give a pan-European approach to the causes and treatment of this problem. The proposal encompasses cross- sectional studies as well as study of the pathophysiological mechanisms underlying existing therapies in COPD. In addition, although the work is mainly to be conducted in humans there is some animal work which paves the way for a pilot study of a novel therapeutic agent in man. A second new treatment approach, which does not involve a pharmacologic agent, is also evaluated. Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-6. - Key action The Ageing Population and Disabilities Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator INSTITUTE OF TUBERCOLOSIS AND LUNG DISEASES EU contribution No data Address Plocka, 26 01-138 WARSAW Poland See on map Total cost No data Participants (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all OSAKJDETZA SERVICIO VASCO DE SALUD Spain EU contribution No data Address Plaza de Cruces s/n 48903 VIZCAYA - BARACALDO See on map Total cost No data THE MAGSTIM COMPANY LIMITED United Kingdom EU contribution No data Address Spring Gardens SA34 O0HR WHITLAND See on map Total cost No data