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Genetic markers for osteoporosis (GENOMOS)

Objective

OSTEOPOROSIS is a common, age-related disease with a strong genetic component. With increasing age of the population, Europe is facing substantial increase inosteoporotic fractures, which account for considerable disease-burden and costs. Early identification and treatment of subjects at risk can help preventing this. Gene polymorphisms, which predispose to osteoporosis, are the most promising risk factors. The AIM of the proposal is to quantify the effect of osteoporosis risk genes, to study the influence of calcium-intake on these effects, and to study the effect of genotype on response to treatment with hormone replacement therapy. Meta-analysis of Europe's largest population studies on osteoporosis is used to detect small, but clinically important risks. The project will result in collection of osteoporosis risk-alleles with quantified risks, which will improve clinical risk-assessment for osteoporosis.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

ERASMUS UNIVERSITEIT ROTTERDAM
Address
Dr. Molewaterplein 50
3015 GE Rotterdam
Netherlands

Participants (7)

AARHUS KOMMUNEHOSPITAL - AARHUS UNIVERSITY HOSPITAL
Denmark
Address
Tage Hansens Gade, 2
8000 Aarhus C
OXAGEN LIMITED
United Kingdom
Address
Milton Park, 91
OX14 4RY Abingdon
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
Hills Road Addenbrooke's Hospital
CB2 2QQ Cambridge
UNIVERSITAIRE INSTELLING ANTWERPEN - UNIVERSITEIT ANTWERPEN
Belgium
Address
1,Universiteitsplein 1
2610 Wilrijk (Antwerpen)
UNIVERSITY OF ABERDEEN
United Kingdom
Address
Polwarth Building, Foresterhill
AB25 2ZD Aberdeen
UNIVERSITY OF FLORENCE
Italy
Address
Viale Pieraccini, 6
50134 Firenze
UNIVERSITY OF IOANNINA
Greece
Address
University Campus
45110 Ioannina