Cel
OSTEOPOROSIS is a common, age-related disease with a strong genetic component. With increasing age of the population, Europe is facing substantial increase inosteoporotic fractures, which account for considerable disease-burden and costs. Early identification and treatment of subjects at risk can help preventing this. Gene polymorphisms, which predispose to osteoporosis, are the most promising risk factors. The AIM of the proposal is to quantify the effect of osteoporosis risk genes, to study the influence of calcium-intake on these effects, and to study the effect of genotype on response to treatment with hormone replacement therapy. Meta-analysis of Europe's largest population studies on osteoporosis is used to detect small, but clinically important risks. The project will result in collection of osteoporosis risk-alleles with quantified risks, which will improve clinical risk-assessment for osteoporosis.
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3015 GE ROTTERDAM
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