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The impact of treatment with acetylcholinesterase inhibitors on Europeans with Alzheimers disease

Objective

AChe I have been shown to afford modest benefits on cognition in AD patients. A systematic review by the Cochrane Collaboration states "the practical importance of these changes to patients is unclear" This study's primary objective is to find clinical evidence for the global efficacy of AChE I. The secondary aim is to develop a picture of the natural history of AD. These outcomes will provide a fundamental insight into the progression and treatment of AD aiding the formulation of European guidelines. This is a prospective 2 year observational study which co-ordinates the centralisation of patient data available within the individual centres. It does not require any modification in prescribing practice of participating centres. Patients will be recruited into either a treated or non-treated patient group and reviewed 6 monthly. The primary outcome measure is a deterioration of one level on the clinical dementia rating scale.

Funding Scheme

CON - Coordination of research actions

Coordinator

CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
Address
Av. De Casselardit, 170
31300 Toulouse
France

Participants (30)

ALZHEIMER EUROPE
Luxembourg
Address
Route De Thionville 145
Luxembourg
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
France
Address
Rue Pascal 54/56
75013 Paris
AUTONOMOUS UNIVERSITY OF BARCELONA
Spain
Address
St Antoni Maria Claret, 171
08041 Barcelona
CENTRE HOSPITALIER ET UNIVERSITAIRE DE BORDEAUX
France
Address
Place Amelie Raba-leon
33076 Bordeaux
CENTRE HOSPITALIER RÉGIONAL ET UNIVERSITAIRE DE LILLE
France
Address
Hopital Roger Salemgro
59037 Lille
CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE
Belgium
Address
Sart Tilman B35
4000 Liege
CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER
France
Address
Rue Augustin Fliche 80
34295 Montpellier
CENTRE HOSPITALIER UNIVERSITAIRE DE NICE
France
Address
Avenue De La Voie Romaine 30
06002 Nice
CENTRO S. GIOVANNI DI DIO - FATEBENEFRATELLI ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO
Italy
Address
Via Pilastroni 4
25125 Brescia
CONSORTIUM OF CANADIAN CENTRES FOR CLINICAL COGNITIVE RESEARCH
Canada
Address
Suite 709, 7015 Mac Leod Trail Sw
T2H 2K6 Calgary
COPENHAGEN UNIVERSITY HOSPITAL
Denmark
Address
Blegdamsvej 9
2100 Koepenhagen
Centre Hospitalier Regional Universitaire de Tours
France
Address
Boulevard Tonnellé 2 Chu Bretonneau
37044 Tours
FUNDACIO ACE. INSTITUT CATALA DE NEUROCIENCIES APLICADES
Spain
Address
Marques De Sentmenat, 35-37
08014 Barcelona
GEORG-AUGUST-UNIVERSITY GOETTINGEN
Germany
Address
Von Siebold Strasse 5
37075 Goettingen
GREEK ALZHEIMER DISEASE AND RELATED DISORDERS ASSOCIATION
Greece
Address
C/o Charisio Old Person Home Ano Touba
Thessaloniki
KAROLINSKA INSTITUTE
Sweden
Address
Huddinge University Hospital
141 86 Huddinge
KINGSHILL RESEARCH CENTRE
United Kingdom
Address
C/o Victoria Hospital, Okus Road
SN1 4HZ Swindon
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
Address
Reinierpostlaan 4
6500 HB Nijmegen
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
Address
Gilmar Drive 9500
92037-0624 San Diego
THE RESEARCH INSTITUTE FOR THE CARE OF THE ELDERLY
United Kingdom
Address
St Martins Hospital, Midford Road
BA2 5RP Bath
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
Address
Prof. Martin Lagos
28040 Madrid
UNIVERSIDAD DE CORDOBA
Spain
Address
Avda Menendez Pidal S/n
14071 Cordoba
UNIVERSIDAD DE NAVARRA
Spain
Address
Avda. Pio Xii, 36
31080 Pamplona
UNIVERSITA DEGLI STUDI DI PERUGIA
Italy
Address
Viale Brunamonti 51 Policlinico Monteluce
06122 Perugia
UNIVERSITY HOSPITAL OF GENEVA
Switzerland
Address
Chemin Pont-bochet 3
1226 Thonex
UNIVERSITY OF GENOVA
Italy
Address
Viale Benedetto Xv, 6
16132 Genova
UNIVERSITY OF MANCHESTER
United Kingdom
Address
Smoothmoor Road
M23 9LT Manchester
UNIVERSITY OF WARWICK
United Kingdom
Address
Gibbet Hill Road
CV4 7AL Coventry
VRIJE UNIVERSITEIT MEDICAL CENTER
Netherlands
Address
De Boelelaan 1117
1007 MB Amsterdam
ZENTRAL INSTITUT FÜR SEELISCHE GESUNDHEIT
Germany
Address

68072 Mannheim