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Content archived on 2024-05-27

The eukaryotic linear motif resource, elm: a new european bioinformatics facility for revealing functional sites in modular proteins

Objective

Reflecting the moduiar nature of eucharistic proteins, several WWW servers (e.g. PFAM, SMART, PROSITE) are dedicated to revealing domains in protein sequences: These servers have become indispensable bio informatics tools. However, there is no resource, which specifically focuses on short functional motifs (targeting peptides. docking modules. phosphorylation sites etc.). Yet these modules are Justas important for function as the larger protein domains. The reason there are no good tools is that the notify are so short that they severely over predict, only acquiring significance in the right context (e.g. KDEL functions in the ER compartment). We will address this deficit by creating and applying ELM, a comprehensive set of tools for evaluating linear notify in eukaryotlc proteins using context-based rules to reduce or eliminate false positives. ELM will be available via the www and in a package for automated genome analysis pipelines.

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Funding Scheme

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Coordinator

EUROPEAN MOLECULAR BIOLOGY LABORATORY
EU contribution
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Address
Meyerhofstrasse 1
69012 HEIDELBERG
Germany

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Participants (5)

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