Objetivo
This proposal enhances infrastructure provision for the efficient exploitation of rodent models leading to the identification of genes and their biological validation. These genes and pathways are then potential targets for therapeutic intervention. The key areas for development are: Discovery of rat and mouse Snips and construction of mapping panel coupled with the development of very high throughput SNP genotyping technology based on mass spectrometry resulting in more efficient QTL mapping. Mouse cosmic panel and associated resource generation to facilitate QTL refinement mapping. Cross species and specialised tissue expression profiling to identify genes underlying Atlas and the pathways relevant to these traits. Comparative, QTL and Pathway gene maps to facilitate correlation with Atlas mapped in different species (Human, rat and mouse). Genotype driven recovery of an ENU allelic series in mouse to functionally validate genes of interest.
Ámbito científico
Convocatoria de propuestas
Data not availableRégimen de financiación
CSC - Cost-sharing contractsCoordinador
OX11 0RD DIDCOT,HARWELL,CHILTON
Reino Unido