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Contenido archivado el 2024-05-27

Pilot-study for a human epigenome project

Objetivo

For an elucidation of complex human disease, all available sources of biological information are required. Biological information sources are DNA, mRNA, proteins, metabolic networks and epigenetic information in the form of chromatin structure and DNA-methylamine. DNA-methylamine is tissue specific and correlates with gene- expression, hence being a likely contributor to pathogenesis. The pilot-project proposed will demonstrate the methylamine blueprint of two different human tissues for a selected 4 Mb genomic region, the Major Histocompatibility Complex (MHC) by genomic sequencing. The MHC is the most polymorphism genomic region known, the densest in genes and displays association with a number of diseases. In addition, correlations between heliotypes associated with Psoriasis, an MHC-linked disease and methylamine epigenotypes will establish reproducible inter-individual, disease related variation of methylamine patterns.

Convocatoria de propuestas

Data not available

Régimen de financiación

CSC - Cost-sharing contracts

Coordinador

GENOME RESEARCH LTD.
Aportación de la UE
Sin datos
Dirección
The Wellcome Trust Genome Campus Hinxton
CB10 1SA SAFFRON WALDEN
Reino Unido

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Coste total
Sin datos

Participantes (1)