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Euroas European genomic bank and clinical, genetic and immunogenetic databases of ankylosing Spondylitys and the other Spondylarthropathes

Objective

Existing infrastructures of partner laboratories and clinical leading centres in European countries will be harmonised and reinforced into a task force to achieve clinical (phenotypes), genetic material and genotype repository from anklylosing sodalities (AS) and the other spondylarthropathies (SPA), thanks to the access to up to 00 affected families. After diagnostic ascertaining, informative families will be recruited. All needed clinical data (including severity assessment, co morbidities) from AS patients and unaffected individuals will be collected. DNA, cells, sera and transformed cell lines (EBV) will be stored in a central bank for researcher use. Only such a large repository will give enough power to monogenetic, candidate gene, genome wide screen and fine gene mapping studies to successfully identify new AS susceptibility and severity genes, allowing the development of new therapeutic (gene therapy) and preventive approaches.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
Address
Rue Du Fbg. St. Jacques 27, Hopital Cochin
75674 Paris
France

Participants (10)

CENTRO DE HISTOCOMPATIBILIDADE DO NORTE
Portugal
Address
Rua Dr. Roberto Frias
4200-467 Porto
GENETHON III
France
Address
Rue De L'internationale 1Bis
91002 Evry
HANNOVER MEDICAL SCHOOL
Germany
Address
Carl-neuberg-strasse 1
30625 Hannover
HLA ET MÉDECINE
France
Address
15,Rue De L'ecole De Médecine 15
75006 Paris
P. STRADINA CLINICAL UNIVESITY HOSPITAL
Latvia
Address
Pilsonu Street, 13
1002 Riga
UNIVERSIDAD DE OVIEDO
Spain
Address
Julian Claveria S/n
33006 Oviedo
UNIVERSITY HOPSITAL OF GENT
Belgium
Address
De Pintelaan 185
9000 Gent
UNIVERSITY OF FLORENCE
Italy
Address
Viale Pieraccini, 18
50139 Firenze
UNIVERSITY OF HELSINKI
Finland
Address
Haartmaninkatu 8, Biomedicum Helsinki
00014 Helsinki
UNIVERSITY OF LEEDS
United Kingdom
Address
Clarendon Road 36
LS2 9NZ Leeds