Euroas European genomic bank and clinical, genetic and immunogenetic databases of ankylosing Spondylitys and the other Spondylarthropathes

Objective

Existing infrastructures of partner laboratories and clinical leading centres in European countries will be harmonised and reinforced into a task force to achieve clinical (phenotypes), genetic material and genotype repository from anklylosing sodalities (AS) and the other spondylarthropathies (SPA), thanks to the access to up to 00 affected families. After diagnostic ascertaining, informative families will be recruited. All needed clinical data (including severity assessment, co morbidities) from AS patients and unaffected individuals will be collected. DNA, cells, sera and transformed cell lines (EBV) will be stored in a central bank for researcher use. Only such a large repository will give enough power to monogenetic, candidate gene, genome wide screen and fine gene mapping studies to successfully identify new AS susceptibility and severity genes, allowing the development of new therapeutic (gene therapy) and preventive approaches.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-14. - Support for research infrastructures

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

Address

Rue Du Fbg. St. Jacques 27, Hopital Cochin
75674 Paris
France

Participants (10)

CENTRO DE HISTOCOMPATIBILIDADE DO NORTE

Portugal

Address

Rua Dr. Roberto Frias
4200-467 Porto

GENETHON III

France

Address

Rue De L'internationale 1Bis
91002 Evry

HANNOVER MEDICAL SCHOOL

Germany

Address

Carl-neuberg-strasse 1
30625 Hannover

HLA ET MÉDECINE

France

Address

15,Rue De L'ecole De Médecine 15
75006 Paris

P. STRADINA CLINICAL UNIVESITY HOSPITAL

Latvia

Address

Pilsonu Street, 13
1002 Riga

UNIVERSIDAD DE OVIEDO

Spain

Address

Julian Claveria S/n
33006 Oviedo

UNIVERSITY HOPSITAL OF GENT

Belgium

Address

De Pintelaan 185
9000 Gent

UNIVERSITY OF FLORENCE

Italy

Address

Viale Pieraccini, 18
50139 Firenze

UNIVERSITY OF HELSINKI

Finland

Address

Haartmaninkatu 8, Biomedicum Helsinki
00014 Helsinki

UNIVERSITY OF LEEDS

United Kingdom

Address

Clarendon Road 36
LS2 9NZ Leeds