Objective
Existing infrastructures of partner laboratories and clinical leading centres in European countries will be harmonised and reinforced into a task force to achieve clinical (phenotypes), genetic material and genotype repository from anklylosing sodalities (AS) and the other spondylarthropathies (SPA), thanks to the access to up to 00 affected families. After diagnostic ascertaining, informative families will be recruited. All needed clinical data (including severity assessment, co morbidities) from AS patients and unaffected individuals will be collected. DNA, cells, sera and transformed cell lines (EBV) will be stored in a central bank for researcher use. Only such a large repository will give enough power to monogenetic, candidate gene, genome wide screen and fine gene mapping studies to successfully identify new AS susceptibility and severity genes, allowing the development of new therapeutic (gene therapy) and preventive approaches.
Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
75674 Paris
France
Participants (10)
4200-467 Porto
91002 Evry
30625 Hannover
75006 Paris
1002 Riga
33006 Oviedo
9000 Gent
50139 Firenze
00014 Helsinki
LS2 9NZ Leeds