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Structural and functional genomics tools for cattle research

Objective

The objective of the proposed work is to develop advanced genomic tools that will help researchers to identify the genes involved in important traits in cattle, starting either from their map position, or from examining expression profiles. A set of 20,000 non-redundant cDNAs will be sequenced. These cDNAS will be used to construct macro-and micro-arrays, which can be used to examine gene expression under various physiological conditions. The sequence information will also be used to construct a high-density "gene map" of the bovine genome and hence high-resolution comparative genome maps with man and mouse. The latter will aid the identification of postional candidate genes for mapped traits. The sequence information and RH maps will also be used to in collaboration with an international project to construct a scaffold physical (BAC) map of the entire bovine genome, which will be as entry for targeted DNA sequencing.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

ROSLIN INSTITUTE (EDINBURGH)
Address

EH25 9PS Roslin, Midlothian
United Kingdom

Participants (5)

CATHOLIC UNIVERSITY OF SACRED HEART
Italy
Address
84,Via Emilia Parmense 84
29100 Piacenza
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
France
Address
Domaine De Vilvert
78352 Jouy-en-josas
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Germany
Address
73,Ihnestraße 73
14195 Berlin
UNIVERSITY OF ALBERTA
Canada
Address
410 Agfor Centre, University Of Alberta
T6G 2P Edmonton
UNIVERSITÀ DEGLI STUDI DELLA TUSCIA
Italy
Address
Via De Lellis
01100 Viterbo