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Contenido archivado el 2024-05-24

Glucocorticoid hormone programming in early life and its impact on adult health

Objetivo

Low birth weight in humans is associated with increased risk of hypertension, diabetes or affective disorders in later life. Excessive foetal exposure to glucocorticoids (GCs) retards organism growth, as GCs exert prenatal programming in a variety of target tissues. Whilst many researchers have argued on the basis of conventional animal models to explain the links between prenatal GC exposure and the commonest human disorders, none has shown strict relevance to humans. To elucidate the mechanisms in a primate model, we propose extending the studies in rats to marmoset monkeys. The animals will be treated prenatally with GCs, studying the impact upon potential adverse metabolic programming, reproductive and immune function, HPA axis activity, brain function and morphology and behaviour. Understanding how such prenatal programming works provides prospects for disease prevention and health promotion.

Ámbito científico

CORDIS clasifica los proyectos con EuroSciVoc, una taxonomía plurilingüe de ámbitos científicos, mediante un proceso semiautomático basado en técnicas de procesamiento del lenguaje natural.

Convocatoria de propuestas

Data not available

Régimen de financiación

CSC - Cost-sharing contracts

Coordinador

DEUTSCHES PRIMATENZENTRUM GMBH
Aportación de la UE
Sin datos
Dirección
4,Kellnerweg 4
37077 GOETTINGEN
Alemania

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Coste total
Sin datos

Participantes (6)