Objective
The goal of this project was to develop a new concept for a small-diameter vascular prosthesis which interacts with the human biological system. This research developed and tested a special polymer type and coated it with cells from the human umbilical vein to encourage its compatibility with the body.
THIS RESEARCH PROJECT WILL MAKE A DECISIVE CONTRIBUTION TO DEVOLOPING A POLYMER FOR USE AS A CARDIOVASCULAR IMPLANT.
FOR THE FIRST TIME, THE ATTEMPT WILL BE MADE TO COLONIZE A SYNTHETIC POLYMER DURABLY WITH HUMAN INTIMA CELLS BY BONDING A NATURAL ADHESION PROMOTER COVALENTLY TO THE POLYMER SURFACE. AS THE SUPPORT POLYMER, A SEMIPERMEABLE, BIOCOMPATIBLE POLYURETHANE FILM IS TO BE DEVELOPED.
BEFORE THE BIOPOLYMER IS APPLIED, SUITABLE FUNCTIONAL GROUPS WILL BE GRAFTED TO THE SURFACE OF THE POLYETHER URETHANE BY PLASMA POLYMERIZATION.
THE CONCEPT DESCRIBED WILL BE FEASIBLE ONLY BY COMBINING THE EXPERIENCE OF SEVERAL DISCIPLINES, SUCH AS INDUSTRIAL POLYMER PROCESSING, POLYMER CHEMISTRY AND CELL BIOCHEMISTRY.
THE DEVELOPMENT OF A POLYETHER URETHANE FILM COLONIZED WITH ENDOTHELIAL CELLS WILL ALLOW THE EUROPEAN INDUSTRY TO PENETRATE FURTHER INTO THE INTERNATIONAL MARKET FOR BIOCOMPATIBLE POLYMERS. THE "ARTIFICIAL VESSELS" NOW ON THE MARKET ARE ONLY OF LIMITED USEFULNESS AND HAVE TO BE IMPROVED.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry
- natural sciences chemical sciences polymer sciences polyurethane
- medical and health sciences medical biotechnology implants
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Data not available
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
52056 AACHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.