Objective The presence of genotoxic compounds such as heterocyclic amines has been demonstrated in foodstuffs submitted to excessive heating, however, toxicologists are not yet able to agree on maximum exposure levels that can be tolerated by humans. The objective of the project was to support collaborative studies aimed at evaluating the best methods of determination of a series of genotoxic compounds in food matrices. A first intercomparison addressed the instrumental determination of 3 imidazoquinolines (IQ, Me-IQ, Me-IQx) in methanol and showed that whereas the high performance liquid chromatography (HPLC) method worked well, gas liquid chromatography (GLC) was unsatisfactory. Good correlation was obtained for the mutagenicity test (Ames test) and showed a very high mutagenic activity for these compounds. A second intercomparison on the determination of the same compounds in specially prepared meat extract has been carried out.Concern about long term exposure to carcinogenic substances which may be present at trace levels in the human diet has greatly increased in the last decade. This has resulted in the development of government regulations, quality control and improvement of industrial food processing.The presence of genotoxic compounds such as heterocyclic amines has been demonstrated in foodstuffs submitted to excessive heating, however, toxicologists are not yet able to agree on maximum exposure levels that can be tolerated by humans.The objective of the project is to support collaborative studies aimed at evaluating the best methods of determination of a series of genotoxic compounds in food matrices. Reference materials will also be prepared, if necessary. Fields of science engineering and technologyother engineering and technologiesfood technologymedical and health scienceshealth sciencesnutritionnatural scienceschemical sciencesorganic chemistryalcoholsnatural scienceschemical sciencesorganic chemistryamines Programme(s) FP2-BCR 4 - Research and development programme (EEC) in the field of applied metrology and chemical analysis (Community Bureau of Reference - BCR), 1988-1992 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator Université Catholique de Louvain EU contribution No data Address 72,Av. E. Mounier 1200 BRUXELLES Belgium See on map Total cost No data Participants (13) Sort alphabetically Sort by EU Contribution Expand all Collapse all Bayerische Julius-Maximilians-Universität Würzburg Germany EU contribution No data Address Versbacher Straße 97078 Würzburg See on map Total cost No data Biochemisches Institut für Umweltcarcinogene Germany EU contribution No data Address Sieker Landstraße 19 22926 Ahrensburg See on map Total cost No data British Industrial Biological Research Association (BIBRA) United Kingdom EU contribution No data Address Woodmansterne Road SM5 4DS Carshalton See on map Total cost No data Conservatoire National des Arts et Métiers (CNAM) France EU contribution No data Address 292 rue St Martin 75141 Paris See on map Total cost No data Federal Research Centre for Nutrition Germany EU contribution No data Address Haid-und-Neustr.9 76131 Karlsruhe See on map Links Website Opens in new window Total cost No data MAFF Food Science Laboratory United Kingdom EU contribution No data Address Norwich Research Park Colney NR4 7UQ Norwich See on map Total cost No data MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH Italy EU contribution No data Address Via Eritrea 62 20157 MILANO See on map Links Website Opens in new window Total cost No data National Food Agency of Denmark Denmark EU contribution No data Address 19,Mörkhöj Bygade 2860 SÖBORG See on map Total cost No data Nestec Ltd Switzerland EU contribution No data Address Vers-chez-les-Blanc 1000 LAUSANNE 26 See on map Total cost No data Rijksinstituut voor Volksgezondheid en Milieuhygiene Netherlands EU contribution No data Address 3720 BA BILTHOVEN See on map Total cost No data United Distillers International United Kingdom EU contribution No data Address Glenochil FK11 7ES Menstrie See on map Total cost No data Università degli Studi di Firenze Italy EU contribution No data Address Viale Morgagni 65 50134 Firenze See on map Total cost No data Università degli Studi di Perugia Italy EU contribution No data Address Via del Giochetto 06100 Perugia See on map Total cost No data
