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NEW PERSPECTIVE IN DNA PHOTOCHEMISTRY

Objective


The understanding of radiation damage sustained by deoxyribonucleic acid (DNA) has been advanced by studies of ultraviolet (UV) light exposure at various wavelengths and intensities. The identity and distributions of photolesions in DNA have been evaluated using synthetic oligodeoxyribonucleotides.

Significant progress has been made on various aspects of deoxyribonucleic acid (DNA) photochemistry including direct ultraviolet (UV) excitation of DNA, photosensitized reactions on DNA and targetting reactions using oligonucleotide photosensitizers.
Studies have been conducted as follows:
detection of photolesions in DNA;
structural characterization of photoproducts;
fluorimetric actinometry;
reactions sensitized by methylene blue, thionine and related compounds;
photosensitization of DNA by ruthenium complexes;
porphyrins as DNA photosensitizers;
interaction of aromatic ketones with DNA components;
photosensitized DNA damage by acetone, riboflavin and ellipticene;
synthesis of oligonucleotide photosensitizer conjugates;
site directed cleavage of DNA by photoreactive oligonucleotides.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN
Address
Trinity College
2 Dublin
Ireland

Participants (1)

MUSEUM NATIONAL D'HISTOIRE NATURELLE
France
Address
57, Rue Cuvier
75231 Paris