Objective The understanding of radiation damage sustained by deoxyribonucleic acid (DNA) has been advanced by studies of ultraviolet (UV) light exposure at various wavelengths and intensities. The identity and distributions of photolesions in DNA have been evaluated using synthetic oligodeoxyribonucleotides.Significant progress has been made on various aspects of deoxyribonucleic acid (DNA) photochemistry including direct ultraviolet (UV) excitation of DNA, photosensitized reactions on DNA and targetting reactions using oligonucleotide photosensitizers.Studies have been conducted as follows:detection of photolesions in DNA;structural characterization of photoproducts;fluorimetric actinometry;reactions sensitized by methylene blue, thionine and related compounds;photosensitization of DNA by ruthenium complexes;porphyrins as DNA photosensitizers;interaction of aromatic ketones with DNA components;photosensitized DNA damage by acetone, riboflavin and ellipticene;synthesis of oligonucleotide photosensitizer conjugates;site directed cleavage of DNA by photoreactive oligonucleotides. Fields of science natural scienceschemical sciencesorganic chemistryketonesnatural sciencesbiological sciencesgeneticsDNAnatural scienceschemical sciencesinorganic chemistrytransition metalsnatural scienceschemical sciencesphysical chemistryphotochemistry Programme(s) FP2-SCIENCE - Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN EU contribution No data Address Trinity College 2 DUBLIN Ireland See on map Total cost No data Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all MUSEUM NATIONAL D'HISTOIRE NATURELLE France EU contribution No data Address 57, Rue Cuvier 75231 PARIS See on map Total cost No data
