Objective
The understanding of radiation damage sustained by deoxyribonucleic acid (DNA) has been advanced by studies of ultraviolet (UV) light exposure at various wavelengths and intensities. The identity and distributions of photolesions in DNA have been evaluated using synthetic oligodeoxyribonucleotides.
Significant progress has been made on various aspects of deoxyribonucleic acid (DNA) photochemistry including direct ultraviolet (UV) excitation of DNA, photosensitized reactions on DNA and targetting reactions using oligonucleotide photosensitizers.
Studies have been conducted as follows:
detection of photolesions in DNA;
structural characterization of photoproducts;
fluorimetric actinometry;
reactions sensitized by methylene blue, thionine and related compounds;
photosensitization of DNA by ruthenium complexes;
porphyrins as DNA photosensitizers;
interaction of aromatic ketones with DNA components;
photosensitized DNA damage by acetone, riboflavin and ellipticene;
synthesis of oligonucleotide photosensitizer conjugates;
site directed cleavage of DNA by photoreactive oligonucleotides.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences organic chemistry ketones
- natural sciences biological sciences genetics DNA
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences chemical sciences physical chemistry photochemistry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2 DUBLIN
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.