Objective
Studies of cardiac excitation contraction coupling will be conducted in a collaboration between a laboratory studying isolated myocytes (Essen), one studying papillary muscles, and subsequently isolated myocytes (Lund) and one studying papillary muscles, intact dogs and humans (London). In each preparation the effects of transient pertubations of beats within a steady train will be studed, i.e. premature excitations, single prolonged depolarisations, and the potentiation and decay which follow these. Interrelationships between systolic and diastolic membrane potential, second inward current, and contractility will be analysed in order to attempt to distinguish the roles of second inward curent, sarcolemmal calcium binding and release, and sodium/calcium exchange,in calcium induced calcium release from the sarcplasmic reticulum, and the regulation of the amount of released calcium.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural scienceschemical sciencesinorganic chemistryalkali metals
- natural scienceschemical sciencesinorganic chemistryalkaline earth metals
- agricultural sciencesanimal and dairy sciencedomestic animals
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Topic(s)
Data not availableCall for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
W6 8RF London
United Kingdom