Objective Studies of cardiac excitation contraction coupling will be conducted in a collaboration between a laboratory studying isolated myocytes (Essen), one studying papillary muscles, and subsequently isolated myocytes (Lund) and one studying papillary muscles, intact dogs and humans (London). In each preparation the effects of transient pertubations of beats within a steady train will be studed, i.e. premature excitations, single prolonged depolarisations, and the potentiation and decay which follow these. Interrelationships between systolic and diastolic membrane potential, second inward current, and contractility will be analysed in order to attempt to distinguish the roles of second inward curent, sarcolemmal calcium binding and release, and sodium/calcium exchange,in calcium induced calcium release from the sarcplasmic reticulum, and the regulation of the amount of released calcium. Fields of science natural scienceschemical sciencesinorganic chemistryalkali metalsnatural scienceschemical sciencesinorganic chemistryalkaline earth metalsagricultural sciencesanimal and dairy sciencedomestic animals Programme(s) FP2-SCIENCE - Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator Charing Cross and Westminster Medical School EU contribution No data Address Fulham Palace Road W6 8RF London United Kingdom See on map Total cost No data Participants (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all Lunds Universitet Sweden EU contribution No data Address 3B,Helgonavagen 223 62 Lund See on map Total cost No data Universität Gesamthochschule Essen Germany EU contribution No data Address Hufelandstraße 55 45147 Essen See on map Total cost No data
