MULTIDISCIPLINARY ANALYSIS OF THE MECHANISM OF CARDIAC EXCITATION- CONTRACTION COUPLING USING THE PRINCIPLE OF TRANSIENT PERTUBATION

Project Information

Grant agreement ID: SC1*0429

Project closed

Start date 1 December 1990

End date 30 November 1993

Funded under

• Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992

Total cost No data

EU contribution No data

Coordinated by

Charing Cross and Westminster Medical School
United Kingdom

Objective

Studies of cardiac excitation contraction coupling will be conducted in a collaboration between a laboratory studying isolated myocytes (Essen), one studying papillary muscles, and subsequently isolated myocytes (Lund) and one studying papillary muscles, intact dogs and humans (London). In each preparation the effects of transient pertubations of beats within a steady train will be studed, i.e. premature excitations, single prolonged depolarisations, and the potentiation and decay which follow these. Interrelationships between systolic and diastolic membrane potential, second inward current, and contractility will be analysed in order to attempt to distinguish the roles of second inward curent, sarcolemmal calcium binding and release, and sodium/calcium exchange,in calcium induced calcium release from the sarcplasmic reticulum, and the regulation of the amount of released calcium.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• natural sciences › chemical sciences › inorganic chemistry › alkali metals
• natural sciences › chemical sciences › inorganic chemistry › alkaline earth metals
• agricultural sciences › animal and dairy science › domestic animals

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Programme(s)

• FP2-SCIENCE - Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992

Topic(s)

Data not available

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

Charing Cross and Westminster Medical School

• EU contribution: No data
• Address: Fulham Palace Road ; W6 8RF London ; United Kingdom
• Total cost: No data

Participants (2)

Lunds Universitet

Sweden

• EU contribution: No data
• Address: 3B,Helgonavagen ; 223 62 Lund
• Total cost: No data

Universität Gesamthochschule Essen

Germany

• EU contribution: No data
• Address: Hufelandstraße 55 ; 45147 Essen
• Total cost: No data