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Vanadium derivates as transition state analogs in ribonucleases and as haptens for the production of antibodyenzymes (abysymes) with phosphatase activity

Objective



The two fundamental goals of this project are:
- The further study of vanadate compounds mainly nucleotides as stable transition-state analogs for pentavalent phosphate
intermediates in reactions catalyzed by ribonuclease-T1. This involves mainly 51V-NMR and X-ray crystallography.
- The exploitation of this property of vanadate compounds to mimic transition state intermediates of phosphohydrolysis reactions, to use them, now as haptens for the production of antibodies with phosphohydrolytic capacity.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

Vrije Universiteit Brussel
Address
65,Paardenstraat 65
1640 Rhode-saint-genèse
Belgium

Participants (2)

FREIE UNIVERSITAET BERLIN
Germany
Address
Kaiserswertherstrasse 16-18
Berlin
UNIVERSITY OF HAMBURG
Germany
Address
Moorweidenstrasse, 18
20148 Hamburg