Vanadium derivates as transition state analogs in ribonucleases and as haptens for the production of antibodyenzymes (abysymes) with phosphatase activity

Objective

The two fundamental goals of this project are:
- The further study of vanadate compounds mainly nucleotides as stable transition-state analogs for pentavalent phosphate
intermediates in reactions catalyzed by ribonuclease-T1. This involves mainly 51V-NMR and X-ray crystallography.
- The exploitation of this property of vanadate compounds to mimic transition state intermediates of phosphohydrolysis reactions, to use them, now as haptens for the production of antibodies with phosphohydrolytic capacity.

Programme(s)

• FP2-SCIENCE - Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

Vrije Universiteit Brussel

Address

65,Paardenstraat 65
1640 Rhode-saint-genèse
Belgium

Participants (2)

FREIE UNIVERSITAET BERLIN

Germany

Address

Kaiserswertherstrasse 16-18
Berlin

UNIVERSITY OF HAMBURG

Germany

Address

Moorweidenstrasse, 18
20148 Hamburg