Vanadium derivates as transition state analogs in ribonucleases and as haptens for the production of antibodyenzymes (abysymes) with phosphatase activity

Projektinformationen

ID Finanzhilfevereinbarung: SC1*0458

Startdatum 1 Februar 1991

Enddatum 31 Juli 1993

Finanziert unter

• Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992

Gesamtkosten € 0,00

EU-Beitrag Keine Daten

Koordiniert durch

Vrije Universiteit Brussel
Belgium

Ziel

The two fundamental goals of this project are:
- The further study of vanadate compounds mainly nucleotides as stable transition-state analogs for pentavalent phosphate
intermediates in reactions catalyzed by ribonuclease-T1. This involves mainly 51V-NMR and X-ray crystallography.
- The exploitation of this property of vanadate compounds to mimic transition state intermediates of phosphohydrolysis reactions, to use them, now as haptens for the production of antibodies with phosphohydrolytic capacity.

Wissenschaftliches Gebiet

• natural sciences › earth and related environmental sciences › geology › mineralogy › crystallography
• natural sciences › chemical sciences › inorganic chemistry › transition metals
• natural sciences › biological sciences › genetics › nucleotides

Programm/Programme

• FP2-SCIENCE - Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992

Thema/Themen

Data not available

Aufforderung zur Vorschlagseinreichung

Data not available

Finanzierungsplan

CSC - Cost-sharing contracts

Koordinator

Vrije Universiteit Brussel

• EU-Beitrag: Keine Daten
• Adresse: 65,Paardenstraat 65 ; 1640 Rhode-Saint-Genèse ; Belgien
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Beteiligte (2)

FREIE UNIVERSITAET BERLIN

Deutschland

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• Adresse: Kaiserswertherstrasse 16-18 ; BERLIN
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UNIVERSITY OF HAMBURG

Deutschland

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• Adresse: Moorweidenstrasse, 18 ; 20148 HAMBURG
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