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Molecular mechanisms and genetic control of DNA - replication in eukaryotic cells

Objective



The understanding of the molecular mechanism and regulation of eukaryotic chromosome replication is a major area of modern biological research. The main reason for this is that DNA is not self-replicating. The replication process is complex and it will be necessary to understand the mechanism of DNA replication and how it is controlled prior to obtaining a complete insight into cellular growth control throughout development and how these controls are reversed during tumorigenesis. The molecular dissection of such a complex molecular process can only be obtained by using model biological systems and a combination of biochemical and genetic experimental strategies.

Coordinator

THE UNIVERSITY OF MILANO
Address
Via Celoria 26
20133 Milano
Italy

Participants (4)

Centre National de la Recherche Scientifique (CNRS)
France
Address
7 Rue Guy Môquet
94802 Villejuif
Institut Curie
France
Address
15 Avenue Georges Clémenceau
91405 Orsay
MRC National Institute for Medical Research
United Kingdom
Address
The Ridgeway Mill Hill
NW7 1AA London
UNIVERSITAET KONSTANZ
Germany
Address
10,Universitaetsstrasse 10
78457 Konstanz