Objectif Amine and peptide levels have been measured in brain samples form Parkinson's Disease (PD) patients as well as from controls both with and without Lewy bodies.Amine measurements showed that dopamine was reduced more in putamen than in caudate nucleus and that ventral subregions showed less alteration than dorsal subregions in PD. However, no differences were found between control samples with or without Lewy bodies.Peptide measurements showed parallel changes in striatal regions of PD samples and those controls with Lewy bodies. These alterations are neither secondary to dopamine nigrostriatal pathway degeneration nor antiparkinsonian therapy.Since the use of peptides as coadjuvants in PD therapy has been suggested, peptide receptors have also been studied. Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesmedical and health sciencesbasic medicineneurologyparkinsonnatural scienceschemical sciencesorganic chemistryamines Programme(s) FP1-STIMULATION 1C - Plan (EEC) to stimulate European scientific and technical cooperation and interchange, 1985-1988 Thème(s) Data not available Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Contribution de l’UE Aucune donnée Adresse Calle Serrano 117 MADRID Espagne Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire Institute of Psychiatry Royaume-Uni Contribution de l’UE Aucune donnée Adresse De Crespigny Park SE5 8AF London Voir sur la carte Coût total Aucune donnée
