Objectif
Bovine Viral Diarrhoea (BVD) is a cosmopolitan disease caused by a pestivirus responsible for various pathological disorders such as digestive, respiratory and genital syndromes and of a debilitating subclinical chronic form. Its main characteristic is a conspicuous immunodepressive action in the host.
Recent findings in our laboratory indicate that:
- in man there is a prevalence of specific antibodies against BVD virus, particularly to the non-cytopathic (NCP) strains
- the contact with susceptible animals is probably an important epidemiological factor
- transmission to man seems to be a world-wide phenomenon
- antibody specificity is confirmed by Western Blotting Test (WBT) - the screening in AIDS patient groups showed slight higher
prevalence for BVDv
- in a first screening of 60 samples, a NCP strain was isolated in 2 buffy coats and recognized by specific anti-BVD sera
The purpose of the proposed research is:
- the further optimization of WBT for BVD virus as reference test for serology in man
- screening on human sera in Europe and Zambia with IIF and
confirmation with WBT
- isolation of Bvdv in human buffy coat samples
- characterization of virus isolates
- evaluation of an eventual etiopathogenic role on diarrhoea, especially in neonates, and genital disorders in man
- comparative study of double infected patients and patients with only HIV infection in order to evaluate the possible interaction of BVD infection with the evolution of HIV infection.
Champ scientifique
Thème(s)
Data not availableAppel à propositions
Data not availableRégime de financement
CSC - Cost-sharing contractsCoordinateur
15780 SANTIAGO DE COMPOSTELA
Espagne