Objective
TRANSMISSION OF MALARIA PARASITES FROM MAN TO MOSQUITO REQUIRES THE PRESENCE OF SEXUAL STAGES IN THE BLOOD BUT THE PROCESS IS DETERMINED BY COMPLICATED AND ENIGMATIC FACTORS. AIM OF THE SEXUAL STAGE VACCINE IS BLOCAGE OF TRANSMISSION, AND KNOWLEDGE ABOUT THE VARIOUS FACTORS HELPS ITS DEVELOPMENT. INFECTIVITY OF GAMETOCYTES IN THE FIELD CANNOT DIRECTLY BE ESTIMATED USING THE PARASITIC DEVELOPMENT BOTH BY FACTORS FROM THE HUMAN HOST AND THE MOSQUITO VECTOR. THE PROJECT APPROACHES TRANSMISSION MECHANISTICS OF PLASMODUM FALCIPARUM IN CAMEROON FROM THE EXPERIMENTAL SIDE AS WELL AS EPIDIOMINOLOGICALLY. THE PRESENCE OF TRANSMISS. REDUCING FACTORS IS DETECTED BY PERFORMING EXPERIMENTAL FEEDINGS OF BLOOD FROM GAMETOCYTE CARRIERS TO LOCALLY REARED ANOPHELINES. THE NATURE OF THESE FACTORS, BE THEY PHASE PROTEINS AND THEIR EFFECTS ALONG THE SPOROGONIC DEVELPMENT WILL BE ANALISED.
THE PRESENCE OF TRANSMISSION
BLOCKAGE IS ALSO DETECTED IN HUMAN POPULATIONS UNDER VARIOUS DEGREES OF EXPOSURE TO INFECTED MOSQUITOS THROUGHOUT THE YEARLY CYCLE OF SEASONS, IN AGE GROUPS AND IN HEALTHY AND SICK PEOPLE. NEWLY DEVELOPED ELISAS FOR ANTIBODIES AGAINST 45/48 AND 230 KD GAMETE PROTEINS WILL BE INTRODUCED AND APPLIED LOCALLY, WHILST A BIO ASSAY WITH CULTURED GAMETOCYTES AND MOSQUITOES IS AT HAND TO EXTEND THE DATA FROM THE FIELD.
THE PROJECT IS A CONCERTED ACTION OF THE UNIVERSITY NIJMEGEN ORSTOM PARIS AND OCEAC YAOUNDE THE REQUESTED DUTCH HALFTIME POSTDOC AND THE AFRICAN PHYSICIAN WILL CARRY OUT MOST OF THEIR RESEARCH IN CAMEROON FOR A PERIOD OF THREE YEARS.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases malaria
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- social sciences psychology ergonomics
- natural sciences biological sciences zoology invertebrate zoology
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Data not available
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
6500 GL NIJMEGEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.