Objetivo During the last two years, a severe selenium deficiency has been documented in Northern Zaire, in an area already characterised by a severe iodine deficiency. It is associated to a peculiarly elevated (1% to 7%) prevalence of myxedematous cretinism as compared to other endemic goiter areas (Latin America, Asia, New Guinea) where neurological cretinism is the predominant form. During a selenium supplementation trial, a drop of serum T4 was observed after two months in initially iodine-& selenium-deficient subjects of Northern zaire. The drop of serum T4 is likely related to the recent biochemical finding that the enzyme converting the prohormone T4 to the active hormone T3 contains selenium at its active site. Iodine deficiency must, thus, be corrected before selenium supplementation. we intend to determine more precisely the link between iodine and selenium deficiency. A first approach is to pursue the determination of the geographical map of iodine and selenium status in different areas of Zaire and in other countries (Tanzania, people's Republic of China). To determine whether the correction of selenium deficiency, in addition to iodine supplementation brings clinical benefits to the general wellbeing of the population, 2000 pregnant women are supplemented with iodine +/- selenium from the first prenatal visit until the sixth month after delivery clinical parameters (neonatal mortality, birthweight, child growth, neurological development), iodine and selenium status (thyroid function parameters, serum selenium, serum and erythrocyte glutathione peroxidase) are assessed during and after the end of selenium supplementation. The effect of selenium deficiency on thyroid hormone metabolism and on clinical thyroid state in subjects who are not iodine deficient is not known. The thyroid function parameters (thyroid hormones, TSH, lipid metabolism parameters, cardiac function tests, TSH response to TRH stimulation) are compared before and 2 months after selenium or placebo supplementation in 160 subjects already treated with iodised oil. The recent development of a device diffusing iodine in drinking water (Rhodiffuse Iodé, Rhône poulenc, France) offers an interesting alternative to iodised 0il in order to supplement villages with iodine. It is proposed to analyse the theoretical aspects of adding also selenium to water by this system. Ámbito científico engineering and technologyenvironmental engineeringwater treatment processesdrinking water treatment processesnatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsnatural scienceschemical sciencesinorganic chemistryhalogensnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymessocial sciencespolitical sciencesgovernment systems Programa(s) FP3-STD 3 - Specific research and technological development programme (EEC) in the field of the life sciences and technologies for developing countries, 1990-1994 Tema(s) Data not available Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador Centre d'Etudes Médicales & Scientifiques de U.L.B. pour les Actions de Coopération Aportación de la UE Sin datos Dirección 2,Bd Kennedy 7000 Mons Bélgica Ver en el mapa Coste total Sin datos Participantes (2) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo United Medical and Dental Schools of Guy's and St Thomas's Hospitals Reino Unido Aportación de la UE Sin datos Dirección St Thomas's Street London Bridge SE1 9RT London Ver en el mapa Coste total Sin datos Université de Kinshasa Aportación de la UE Sin datos Dirección Kinshasa Ver en el mapa Coste total Sin datos