Objective
In the study of human pathogens most of the attention has been given to viral and bacterial species, and fungi have been largely neglected. To date there is no broad, large-scale census of the genomic elements shared by fungal pathogenic species. Also, no large-scale scan for selective pressure variability has been undertaken, even though all the elements are in place to do so. There has neither been a multi-species search for conserved noncoding elements that may be key to explaining the regulation of crucially important functional elements and networks. The overall goal of this study is to gain insight on the evolution of the genomic elements involved in fungal human pathogenicity through the analysis of the selective constraints acting on coding and noncoding sequences. For this purpose we will combine genome sequencing, transcriptomics (RNA-seq), comparative genomics and evolutionary analyses. This project will throw light on fundamental questions about the key genes, regulatory elements and phenotypic traits that are involved in infection or how emergent, opportunistic pathogens originate relatively rapidly from non-pathogenic ancestors. Finally, the list of identified relevant genes and regulatory elements can provide much needed targets for developing pharmaceutical and therapeutic strategies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology mycology
- social sciences sociology demography census
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08003 Barcelona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.