OBESTATIN AS A REGULATOR OF ENERGY BALANCE: NEUROENDOCRINE TARGETS AND MOLECULAR MECHANISMS

Projektinformationen

OBESTATIN

ID Finanzhilfevereinbarung: 40141

Projekt abgeschlossen

Startdatum 1 Mai 2007

Enddatum 31 Dezember 2008

Finanziert unter

• Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Gesamtkosten € 0,00

EU-Beitrag € 157 667,00

Koordiniert durch

UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
Spain

Ziel

Ghrelin is a 28aamino acid peptide derived from a prepropeptide of 117 residues, named pre-proghrelin. Very recently it was identified a new ghrelin-associated peptide encoded by a 23aamino acid peptide, with a flanking conserved glycine residue at the C terminus named obestatin. Obestatin showed a high affinity for GPR39 and needs an amidation to be biologically active.

Regarding its physiological effects, obestatin is able to antagonize ghrelin effects on food intake, body weight and gastric emptying, but had no effect on growth hormone levels. Intraperitoneal and intracerebroventricular injection of obestatin suppressed food intake in a time- and dose-dependent manner. In contrast, treatment with the non-amidated obestatin was less effective. The fact that the same precursor leads to two different peptides with orexigenic and anorexigenic actions shows us that energy balance depends not only of the expression of different peptides but also the rate of transcription from the precursor to aSleana or aSfata gene is very important.

As it is typical when a new discovery appears, numerous unanswered questions arise and further studies will be necessary to find those answers. For instance, even obestatin decreased the food intake and body weight in rodents, serum leptin levels were not affected after treatment with obestatin, suggesting minimal modulation of body-fat content. Moreover, fasting did not change serum obestatin levels and circulating levels of obestatin are much lower than ghrelin, thus the relevance of endogenous obestatin remains unclear. Finally, from a pharmacological point of view, the most interesting will be to check if obestatin changes the food intake or the body weight in humans.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules

Schlüsselbegriffe

• ghrelin
• obesity
• obestatin

Programm/Programme

• FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Thema/Themen

• MOBILITY-2.2 - Marie Curie Outgoing International Fellowships (OIF)

Aufforderung zur Vorschlagseinreichung

FP6-2005-MOBILITY-6
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

OIF - Marie Curie actions-Outgoing International Fellowships

Koordinator

UNIVERSIDADE DE SANTIAGO DE COMPOSTELA

• EU-Beitrag: Keine Daten
• Adresse: Pazo de San Xerome - Praza do Obradoiro s/n ; SANTIAGO DE COMPOSTELA ; Spanien
• Gesamtkosten: Keine Daten

Beteiligte (1)

UNIVERSITY OF CINCINNATI OBESITY RESEARCH CENTRE

Vereinigte Staaten

• EU-Beitrag: Keine Daten
• Adresse: 2170 E Galbraith Road ; CINCINNATI
• Gesamtkosten: Keine Daten