European Multicentre Tics in Children Studies

Project Information

EMTICS

Grant agreement ID: 278367

Project closed

Start date 1 December 2011

End date 31 May 2017

Funded under

• Specific Programme "Cooperation": Health

Total cost € 8 068 217,71

EU contribution € 6 000 000,00

Coordinated by

ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands

Objective

This project will undertake pre-clinical and cohort studies that address susceptibility factors for paediatric and adolescent tic disorders, with a particular focus on comorbid obsessive-compulsive symptomatology, from clinical, epidemiological, genetic, microbiological and immunological angles. EMTICS aims to elucidate the complex aetiology of the onset and clinical course of chronic tic disorders and associated obsessive-compulsive symptoms, through disentangling the interplay between environmental factors and genetic background; translate research findings into clinical applications by developing disease prediction models and investigation of a treatment strategy; and will establish a Pan-European infrastructure for the study of tic disorders. We hypothesise that the onset and/or exacerbation of tic and comorbid obsessive-compulsive disorders is associated with increased preceding occurrence of Group A beta-haemolytic Streptococcus (GAS) infections of specific molecular subtypes, and that this association is based on genetic susceptibility factors and mediated through immunological mechanisms related to psychosocial stress and immunological factors in host and GAS strains. Large-scale cohort studies will involve affected patients and at-risk first-degree relatives within an integrated, multidisciplinary research strategy. Treatment effects of active surveillance and standardized antibiotic treatment of GAS colonisation, thus addressing one of the main environmental factors involved (GAS infections) will be evaluated. Our approach will result in the identification of genetic and environmental susceptibility factors and will greatly contribute to a better understanding of the underlying mechanisms of tic disorders, with a focus on elucidating the role of autoimmunity. Our consortium brings together the highest expertise in the field of tic disorders across Europe in academia and industry, including a number of SMEs and a professional management company.

Fields of science

Not validated

• medical and health sciences › clinical medicine › psychiatry › obsessive-compulsive disorder

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Topic(s)

• HEALTH-2011.2.2.1-3 - Addictive and/or compulsive behaviour in children and adolescents: translating pre-clinical results into therapies

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

ACADEMISCH ZIEKENHUIS GRONINGEN

• EU contribution: € 776 397,00
• Address: HANZEPLEIN 1 ; 9713 GZ Groningen ; Netherlands
• Region: Noord-Nederland › Groningen › Overig Groningen
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Pieter J. Hoekstra (Dr.)
• Total cost: No data

Participants (29)

UNIVERSITA DEGLI STUDI DI BARI ALDO MORO

Italy

• EU contribution: € 241 915,00
• Address: PIAZZA UMBERTO I 1 ; 70121 Bari
• Region: Sud › Puglia › Bari
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Maura Buttiglione (Dr.)
• Total cost: No data

UNIVERSITY COLLEGE LONDON

• EU contribution: € 144 442,00
• Address: GOWER STREET ; WC1E 6BT LONDON
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Greta Borg-Carbott (Ms.)
• Total cost: No data

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

• EU contribution: € 475 965,00
• Address: GESCHWISTER SCHOLL PLATZ 1 ; 80539 MUNCHEN
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Norbert Mueller (Prof.)
• Total cost: No data

URWYLER ADRIAN - CYTOLAB

Switzerland

• EU contribution: € 72 000,00
• Address: RAIRING 66 ; 8108 DALLIKON
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Adrian Urwyler (Mr.)
• Total cost: No data

ISTITUTO SUPERIORE DI SANITA

Italy

• EU contribution: € 713 967,00
• Address: Viale Regina Elena 299 ; 00161 Roma
• Region: Centro (IT) › Lazio › Roma
• Activity type: Research Organisations
• Administrative Contact: Rosa Maria Martoccia (Dr.)
• Total cost: No data

HEALTH PROTECTION AGENCY HPA

Participation ended

United Kingdom

• EU contribution: No data
• Address: BUCKINGHAM PALACE ROAD 151 ; SW1W 9SZ London
• Activity type: Research Organisations
• Administrative Contact: Philip Luton (Dr.)
• Total cost: No data

TECHNISCHE UNIVERSITAET DRESDEN

Germany

• EU contribution: € 289 762,00
• Address: HELMHOLTZSTRASSE 10 ; 01069 Dresden
• Region: Sachsen › Dresden › Dresden, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Carsten Glück (Mr.)
• Total cost: No data

DIMOKRITIO PANEPISTIMIO THRAKIS

Greece

• EU contribution: € 240 541,00
• Address: PANEPISTIMIOUPOLI RECTORATE BUILDING ; 691 00 KOMOTINI
• Region: Βόρεια Ελλάδα › Aνατολική Μακεδονία › Ροδόπη
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Peristera Paschou (Prof.)
• Total cost: No data

PROIMMUNE LTD

United Kingdom

• EU contribution: € 194 760,00
• Address: ROBERT ROBINSON AVENUE THE MAGDALEN ; OX4 4GA OXFORD
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Nikolai Schwabe (Dr.)
• Total cost: No data

GLAXOSMITHKLINE VACCINES SRL

Italy

• EU contribution: € 209 200,00
• Address: VIA FIORENTINA 1 ; 53100 SIENA
• Region: Centro (IT) › Toscana › Siena
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Francesco Gulli (Dr.)
• Total cost: No data

CLALIT HEALTH SERVICES

Israel

• EU contribution: € 225 443,00
• Address: ARLOZOROV STREET 101 ; 62098 Tel Aviv
• Activity type: Research Organisations
• Administrative Contact: Keren Tochterman (Ms.)
• Total cost: No data

THE UNIVERSITY OF BIRMINGHAM

Participation ended

United Kingdom

• EU contribution: No data
• Address: Edgbaston ; B15 2TT Birmingham
• Region: West Midlands (England) › West Midlands › Birmingham
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: May Chung (Ms.)
• Total cost: No data

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

Italy

• EU contribution: € 330 861,00
• Address: Piazzale Aldo Moro 5 ; 00185 Roma
• Region: Centro (IT) › Lazio › Roma
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Francesco Cardona (Dr.)
• Total cost: No data

ADVANCED PRACTICAL DIAGNOSTICS

Belgium

• EU contribution: € 144 360,00
• Address: RAADSHERENSTRAAT 3 ; 2300 Turnhout
• Region: Vlaams Gewest › Prov. Antwerpen › Arr. Turnhout
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Aye Mu Myint (Dr.)
• Total cost: No data

QUEEN MARY UNIVERSITY OF LONDON

United Kingdom

• EU contribution: € 264 928,00
• Address: 327 MILE END ROAD ; E1 4NS London
• Region: London › Inner London — West › Camden and City of London
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Gavin Giovannoni (Prof.)
• Total cost: No data

UNIVERSITA DEGLI STUDI DI CATANIA

Italy

• EU contribution: € 145 646,00
• Address: PIAZZA UNIVERSITA 2 ; 95131 Catania
• Region: Isole › Sicilia › Catania
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Francesco Murabito (Dr.)
• Total cost: No data

CONCENTRIS RESEARCH MANAGEMENT GMBH

Germany

• EU contribution: € 360 000,00
• Address: Ludwigstr. 4 ; 82256 Furstenfeldbruck
• Region: Bayern › Oberbayern › Fürstenfeldbruck
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Ameli Schwalber (Ms.)
• Total cost: No data

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF

Participation ended

Germany

• EU contribution: No data
• Address: Martinistrasse 52 ; 20251 Hamburg
• Region: Hamburg › Hamburg › Hamburg
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Alexander Münchau (Prof.)
• Total cost: No data

VADASKERT ALAPITVANY A GYERMEKEK LELKI EGESZSEGEERT

Hungary

• EU contribution: € 149 605,00
• Address: HUVOSVOLGYI UT 116 ; 1021 BUDAPEST
• Activity type: Research Organisations
• Administrative Contact: Zsanett Tárnok (Dr.)
• Total cost: No data

SERVICIO ANDALUZ DE SALUD

Spain

• EU contribution: € 63 470,00
• Address: AVENIDA DE LA CONSTITUCION 18 ; 41071 Sevilla
• Region: Sur › Andalucía › Sevilla
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Sophie Monteau (Ms.)
• Total cost: No data

University of Zurich

Switzerland

• EU contribution: € 135 023,00
• Address: RAMISTRASSE 71 ; 8006 ZURICH
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Susanne Walitza (Prof.)
• Total cost: No data

FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

Spain

• EU contribution: € 106 846,00
• Address: CARRER ROSSELLO 149 ; 08036 Barcelona
• Region: Este › Cataluña › Barcelona
• Activity type: Research Organisations
• Administrative Contact: Pastora Martinez Samper (Ms.)
• Total cost: No data

REGION HOVEDSTADEN

Denmark

• EU contribution: € 135 016,00
• Address: KONGENS VAENGE 2 ; 3400 Hillerod
• Region: Danmark › Hovedstaden › Nordsjælland
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Pernille Rosling (Ms.)
• Total cost: No data

MEDIZINISCHE HOCHSCHULE HANNOVER

Germany

• EU contribution: € 113 883,00
• Address: Carl-Neuberg-Strasse 1 ; 30625 Hannover
• Region: Niedersachsen › Hannover › Region Hannover
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Frank Dittrich (Mr.)
• Total cost: No data

GUYS AND ST THOMAS' NHS FOUNDATIONTRUST

United Kingdom

• EU contribution: € 179 443,00
• Address: Westminster Bridge Road ; SE1 7EH London
• Region: London › Inner London — East › Lambeth
• Activity type: Research Organisations
• Administrative Contact: Peter Allanson (Mr.)
• Total cost: No data

AZIENDA SANITARIA LOCALE BARI

Italy

• EU contribution: € 84 776,00
• Address: LUNGOMARE STARITA 6 ; 70123 BARI
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Nicola Pansini (Dr.)
• Total cost: No data

UNIVERSITAET zu LUEBECK

Germany

• EU contribution: € 13 187,00
• Address: RATZEBURGER ALLEE 160 ; 23562 Lubeck
• Region: Schleswig-Holstein › Schleswig-Holstein › Lübeck, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Gabriele Kipke (Mrs.)
• Total cost: No data

Department of Health

United Kingdom

• EU contribution: € 148 603,00
• Address: Quarry House, Quarry Hill ; LS2 7UE Leeds
• Region: Yorkshire and the Humber › West Yorkshire › Leeds
• Activity type: Research Organisations
• Administrative Contact: Phil Luton (Dr.)
• Total cost: No data

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Netherlands

• EU contribution: € 39 961,00
• Address: MEIBERGDREEF 15 ; 1105AZ Amsterdam
• Region: West-Nederland › Noord-Holland › Groot-Amsterdam
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Eugenie Quartier (Mrs.)
• Total cost: No data