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European Multicentre Tics in Children Studies

Objective

This project will undertake pre-clinical and cohort studies that address susceptibility factors for paediatric and adolescent tic disorders, with a particular focus on comorbid obsessive-compulsive symptomatology, from clinical, epidemiological, genetic, microbiological and immunological angles. EMTICS aims to elucidate the complex aetiology of the onset and clinical course of chronic tic disorders and associated obsessive-compulsive symptoms, through disentangling the interplay between environmental factors and genetic background; translate research findings into clinical applications by developing disease prediction models and investigation of a treatment strategy; and will establish a Pan-European infrastructure for the study of tic disorders. We hypothesise that the onset and/or exacerbation of tic and comorbid obsessive-compulsive disorders is associated with increased preceding occurrence of Group A beta-haemolytic Streptococcus (GAS) infections of specific molecular subtypes, and that this association is based on genetic susceptibility factors and mediated through immunological mechanisms related to psychosocial stress and immunological factors in host and GAS strains. Large-scale cohort studies will involve affected patients and at-risk first-degree relatives within an integrated, multidisciplinary research strategy. Treatment effects of active surveillance and standardized antibiotic treatment of GAS colonisation, thus addressing one of the main environmental factors involved (GAS infections) will be evaluated. Our approach will result in the identification of genetic and environmental susceptibility factors and will greatly contribute to a better understanding of the underlying mechanisms of tic disorders, with a focus on elucidating the role of autoimmunity. Our consortium brings together the highest expertise in the field of tic disorders across Europe in academia and industry, including a number of SMEs and a professional management company.

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

ACADEMISCH ZIEKENHUIS GRONINGEN
Address
Hanzeplein 1
9713 GZ Groningen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 776 397
Administrative Contact
Pieter J. Hoekstra (Dr.)

Participants (29)

UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italy
EU contribution
€ 241 915
Address
Piazza Umberto I 1
70121 Bari
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maura Buttiglione (Dr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 144 442
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 475 965
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Norbert Mueller (Prof.)
URWYLER ADRIAN - CYTOLAB
Switzerland
EU contribution
€ 72 000
Address
Rairing 66
8108 Dallikon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Adrian Urwyler (Mr.)
ISTITUTO SUPERIORE DI SANITA
Italy
EU contribution
€ 713 967
Address
Viale Regina Elena 299
00161 Roma
Activity type
Research Organisations
Administrative Contact
Rosa Maria Martoccia (Dr.)
Public Health England an Executive Agency of the Dept of Health

Participation ended

United Kingdom
Address
Waterloo Road
SE1 8UG London
Activity type
Research Organisations
Administrative Contact
Philip Luton (Dr.)
TECHNISCHE UNIVERSITAET DRESDEN
Germany
EU contribution
€ 289 762
Address
Helmholtzstrasse 10
01069 Dresden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Carsten Glück (Mr.)
DIMOKRITIO PANEPISTIMIO THRAKIS
Greece
EU contribution
€ 240 541
Address
Panepistimioupoli Rectorate Building
69100 Komotini
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peristera Paschou (Prof.)
PROIMMUNE LTD
United Kingdom
EU contribution
€ 194 760
Address
Robert Robinson Avenue The Magdalen
OX4 4GA Oxford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nikolai Schwabe (Dr.)
GLAXOSMITHKLINE VACCINES SRL
Italy
EU contribution
€ 209 200
Address
Via Fiorentina 1
53100 Siena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Francesco Gulli (Dr.)
CLALIT HEALTH SERVICES
Israel
EU contribution
€ 225 443
Address
Arlozorov Street 101
62098 Tel Aviv
Activity type
Research Organisations
Administrative Contact
Keren Tochterman (Ms.)
THE UNIVERSITY OF BIRMINGHAM

Participation ended

United Kingdom
Address
Edgbaston
B15 2TT Birmingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
May Chung (Ms.)
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Italy
EU contribution
€ 330 861
Address
Piazzale Aldo Moro 5
00185 Roma
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Francesco Cardona (Dr.)
ADVANCED PRACTICAL DIAGNOSTICS
Belgium
EU contribution
€ 144 360
Address
Raadsherenstraat 3
2300 Turnhout
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Aye Mu Myint (Dr.)
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
EU contribution
€ 264 928
Address
327 Mile End Road
E1 4NS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gavin Giovannoni (Prof.)
UNIVERSITA DEGLI STUDI DI CATANIA
Italy
EU contribution
€ 145 646
Address
Piazza Universita 2
95131 Catania
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Francesco Murabito (Dr.)
Concentris Research Management GmbH
Germany
EU contribution
€ 360 000
Address
Ludwigstr. 4
D-82256 Fürstenfeldbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ameli Schwalber (Ms.)
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF

Participation ended

Germany
Address
Martinistrasse 52
20251 Hamburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alexander Münchau (Prof.)
VADASKERT ALAPITVANY A GYERMEKEK LELKI EGESZSEGEERT
Hungary
EU contribution
€ 149 605
Address
Huvosvolgyi Ut 116
1021 Budapest
Activity type
Research Organisations
Administrative Contact
Zsanett Tárnok (Dr.)
SERVICIO ANDALUZ DE SALUD
Spain
EU contribution
€ 63 470
Address
Avenida De La Constitucion 18
41071 Sevilla
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Sophie Monteau (Ms.)
University of Zurich
Switzerland
EU contribution
€ 135 023
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Susanne Walitza (Prof.)
FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA
Spain
EU contribution
€ 106 846
Address
Carrer Rossello 149
08036 Barcelona
Activity type
Research Organisations
Administrative Contact
Pastora Martinez Samper (Ms.)
REGION HOVEDSTADEN
Denmark
EU contribution
€ 135 016
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Pernille Rosling (Ms.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 113 883
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Dittrich (Mr.)
GUYS AND ST THOMAS' NHS FOUNDATIONTRUST
United Kingdom
EU contribution
€ 179 443
Address
Westminster Bridge Road
SE1 7EH London
Activity type
Research Organisations
Administrative Contact
Peter Allanson (Mr.)
AZIENDA SANITARIA LOCALE BARI
Italy
EU contribution
€ 84 776
Address
Lungomare Starita 6
70123 Bari
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Nicola Pansini (Dr.)
UNIVERSITAET zu LUEBECK
Germany
EU contribution
€ 13 187
Address
Ratzeburger Allee 160
23562 Lubeck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gabriele Kipke (Mrs.)
Department of Health
United Kingdom
EU contribution
€ 148 603
Address
Quarry House, Quarry Hill
LS2 7UE Leeds
Activity type
Research Organisations
Administrative Contact
Phil Luton (Dr.)
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 39 961
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eugenie Quartier (Mrs.)