Objective
In 2009 protein AMPylation, the reversible post-translational adenylation of target proteins with adenosine monophosphate (AMP), was first revealed as a novel mechanism for pathogenic bacteria to target and disrupt interactions of host GTPases with their cognate binding partners. Furthermore, there is growing evidence that AMPylation also operates as a general intracellular signaling mechanism in normal cell function. This novel post-translational modification is catalyzed by AMP transferases containing a so-called Fido motif that has been found across prokaryotes and eukaryotes, in over 2700 putative bacterial and mammalian proteins. Consequently, AMPylation is rapidly emerging as a fundamental mechanism to regulate protein-protein interactions and cell signaling in normal cells and in host-pathogen interactions, providing an opportunity for the discovery of new biology and targets for new antibiotics with novel mode of action. However, without robust tools to identify and manipulate both AMP transferases and their AMPylated protein substrates, our understanding of this complex signaling network will remain superficial.
This Fellowship project aims to develop and apply chemical probes and technologies that will enable for the first time high-throughput analysis and exploration of the complex biological networks involved in protein AMPylation. These chemical tools will be applied to mapping the changes in AMPylation that occur during bacterial infection in the host and the pathogen, with the ultimate objective of identifying and validating cellular mechanisms that can be targeted for future antimicrobial therapy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences cell biology cell signaling
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SW7 2AZ London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.