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Rapid development and distribution of statistical tools for high-throughput sequencing data

Objetivo

High-throughput sequencing (HTS) is a powerful and rapidly evolving family of technologies with a multitude of applications. They include genetics of rare and common diseases, understanding of disease mechanism and progression through transcriptome and epigenome profiling, cancer stratification, personalised medicine and molecular systems biology of gene regulation. The genome, epigenome, transcriptome and interactome are all intricately connected, and modern HTS technology can probe all of these -omic levels. Statistical analysis is a crucial component of many experiments and studies, and the quality and efficiency of the analysis often determines the success of a project.

In this collaborative project we will develop a range of new statistical analysis tools to solve open problems in HTS data analysis, ranging from low-level processing of sequence reads up to systems-level modelling of disease associated and cellular processes. We will provide to a wide audience an integrated computational framework for HTS data analysis and interpretation that is robust, efficient and user-friendly. We will establish improved procedures for the publishing of statistical software as an integral part of the scientific publication process, within the framework of the Bioconductor project. We will provide tools to benchmark experimental protocols and statistical methods, and we will provide training materials and a extensive training programme to rapidly disseminate these new tools to the broader biomedical community.

SME partners will integrate these new tools within their analysis pipelines with associated user-friendly commercial software providing access to their additional proprietary tools. SMEs will benefit from basic methodology development done in a public, pre-competitive arena and will be able to use these technologies to enhance their products and services.

Ámbito científico

  • /ciencias naturales/ciencias biológicas/genética y herencia genética
  • /ciencias naturales/informática y ciencias de la información/software
  • /ciencias naturales/ciencias biológicas/genética y herencia genética/genoma
  • /ciencias sociales/sociología/gobernanza/servicios públicos
  • /ciencias naturales/informática y ciencias de la información/ciencia de datos/análisis de datos

Convocatoria de propuestas

FP7-HEALTH-2012-INNOVATION-1
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Régimen de financiación

CP-FP - Small or medium-scale focused research project

Coordinador

THE UNIVERSITY OF MANCHESTER
Dirección
Oxford Road
M13 9PL Manchester
United Kingdom
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de la UE
€ 635 452
Contacto administrativo
Katherine Boylan (Dr.)

Participantes (9)

Genomatix Software GmbH
Alemania
Aportación de la UE
€ 439 000
Dirección
Bayerstrasse 85A
80335 Muenchen
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Korbinian Grote (Dr.)
GENOMNIA SRL
Italia
Aportación de la UE
€ 306 059,60
Dirección
Corso Magenta 56
20123 Milano
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Cinzia Ferraro (Mrs.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Alemania
Aportación de la UE
€ 531 472,20
Dirección
Meyerhofstrasse 1
69117 Heidelberg
Tipo de actividad
Research Organisations
Contacto administrativo
Virginia Otón García (Ms.)
FONDAZIONE TELETHON
Italia
Aportación de la UE
€ 187 500
Dirección
Via Varese 16/B
00185 Roma
Tipo de actividad
Research Organisations
Contacto administrativo
Irene Mearelli (Mrs.)
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italia
Aportación de la UE
€ 256 862,40
Dirección
Via Morego 30
16163 Genova
Tipo de actividad
Research Organisations
Contacto administrativo
Alessandra Gastaldi (Ms.)
ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS
Francia
Aportación de la UE
€ 315 428
Dirección
Boulevard Saint Michel 60
75272 Paris
Tipo de actividad
Research Organisations
Contacto administrativo
Florence Thépenier (Mrs.)
UNIVERSITAT ZURICH
Suiza
Aportación de la UE
€ 356 758
Dirección
Ramistrasse 71
8006 Zürich
Tipo de actividad
Other
Contacto administrativo
Mark Robinson (Prof.)
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Aportación de la UE
€ 268 776
Dirección
Trinity Lane The Old Schools
CB2 1TN Cambridge
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Renata Shaeffer (Ms.)
THE UNIVERSITY OF SHEFFIELD
United Kingdom
Aportación de la UE
€ 374 941,20
Dirección
Firth Court Western Bank
S10 2TN Sheffield
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Joanne Watson (Ms.)