CORDIS
Resultados de investigaciones de la UE

CORDIS

Español ES
Rapid development and distribution of statistical tools for high-throughput sequencing data

Rapid development and distribution of statistical tools for high-throughput sequencing data

Objetivo

High-throughput sequencing (HTS) is a powerful and rapidly evolving family of technologies with a multitude of applications. They include genetics of rare and common diseases, understanding of disease mechanism and progression through transcriptome and epigenome profiling, cancer stratification, personalised medicine and molecular systems biology of gene regulation. The genome, epigenome, transcriptome and interactome are all intricately connected, and modern HTS technology can probe all of these -omic levels. Statistical analysis is a crucial component of many experiments and studies, and the quality and efficiency of the analysis often determines the success of a project.

In this collaborative project we will develop a range of new statistical analysis tools to solve open problems in HTS data analysis, ranging from low-level processing of sequence reads up to systems-level modelling of disease associated and cellular processes. We will provide to a wide audience an integrated computational framework for HTS data analysis and interpretation that is robust, efficient and user-friendly. We will establish improved procedures for the publishing of statistical software as an integral part of the scientific publication process, within the framework of the Bioconductor project. We will provide tools to benchmark experimental protocols and statistical methods, and we will provide training materials and a extensive training programme to rapidly disseminate these new tools to the broader biomedical community.

SME partners will integrate these new tools within their analysis pipelines with associated user-friendly commercial software providing access to their additional proprietary tools. SMEs will benefit from basic methodology development done in a public, pre-competitive arena and will be able to use these technologies to enhance their products and services.

Coordinador

THE UNIVERSITY OF MANCHESTER

Dirección

Oxford Road
M13 9pl Manchester

Reino Unido

Tipo de actividad

Higher or Secondary Education Establishments

Aportación de la UE

€ 635 452

Contacto administrativo

Katherine Boylan (Dr.)

Participantes (9)

Ordenar alfabéticamente

Ordenar por aportación de la UE

Ampliar todo

Genomatix Software GmbH

Alemania

Aportación de la UE

€ 439 000

GENOMNIA SRL

Italia

Aportación de la UE

€ 306 059,60

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Alemania

Aportación de la UE

€ 531 472,20

FONDAZIONE TELETHON

Italia

Aportación de la UE

€ 187 500

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

Italia

Aportación de la UE

€ 256 862,40

ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS

Francia

Aportación de la UE

€ 315 428

UNIVERSITAT ZURICH

Suiza

Aportación de la UE

€ 356 758

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

Reino Unido

Aportación de la UE

€ 268 776

THE UNIVERSITY OF SHEFFIELD

Reino Unido

Aportación de la UE

€ 374 941,20

Información del proyecto

Identificador del acuerdo de subvención: 305626

Estado

Proyecto cerrado

  • Fecha de inicio

    1 Diciembre 2012

  • Fecha de finalización

    30 Noviembre 2015

Financiado con arreglo a:

FP7-HEALTH

  • Presupuesto general:

    € 4 675 174

  • Aportación de la UE

    € 3 672 249,40

Coordinado por:

THE UNIVERSITY OF MANCHESTER

Reino Unido