Objective The regenerative power of a living organism is linked to the potential of its stem cells to replace the corresponding damaged tissue. Therefore organisms are as old as their stem cells. Whereas the vulnerability to cancer and chronic inflammation is associated with a decline of the immune system, the latter is in turn a sum product of interactions among hematopoietic stem cells (HSC), endothelial cells (EC) of the vascular systems and the microenvironment in the bone marrow, among others. Hence loss of regenerative function and propensity to contract cancers can be interpreted as harbingers of ageing at the level of somatic stem cells. Using HSC and their microenvironment as a model, our principal goal is to develop a systems-level understanding of the molecular mechanisms of ageing in somatic stem cells, the consequences, and means to correct these age-related alterations and diseases. We intend to apply integrative systems biology approaches to characterize the molecular players, genes and pathways that are associated with physiological processes of ageing and two age-related disorders, myelodysplastic syndromes (MDS) and B-cell chronic lymphocytic leukemia (B-CLL). We will use the resulting models of ageing to develop novel, molecular targeted strategies to treat age-related diseases. The SyStemAge consortium involves three hospital departments that are active in implementing innovative treatment strategies of leukaemia and MDS, a number of biomedical departments engaged with basic research in the processes underlying these diseases, two Systems Biology groups, one of Europe’s most experienced group in biomedical modelling and complex systems theory and two SMEs with proven expertise in the translation of biomedical models in novel therapy strategies in humans. SyStemAge is uniquely positioned to bridge the gap between the clinical, biomedical and natural sciences and immediately contribute to bio-gerontology. Fields of science natural sciencesmedical and health sciencesbasic medicineimmunologymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineoncologyleukemia Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2012.2.2.2-1 - Integrative systems biology and comparative genomics for studying human ageing and/or most common age-related diseases Call for proposal FP7-HEALTH-2012-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator EUROPEAN MOLECULAR BIOLOGY LABORATORY EU contribution € 930 334,70 Address Meyerhofstrasse 1 69117 Heidelberg Germany See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Administrative Contact Jillian Rowe (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all ALMAZOV FEDERAL HEART, BLOOD AND ENDOCRINOLOGY CENTRE, FEDERATION AGENCY ON HIGH MEDICAL TECHNOLOGIES Russia EU contribution € 133 200,90 Address Akkuratova Str. 2 197341 Saint-Petersburg See on map Activity type Research Organisations Administrative Contact Yulia Lukianchikova (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ANAXOMICS BIOTECH SL Spain EU contribution € 1 423 239,76 Address CALLE DIPUTACIO 237, P 1 PTA 1 08007 Barcelona See on map Region Este Cataluña Barcelona Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Vesna Radovanovic (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Germany EU contribution € 823 186,00 Address IM NEUENHEIMER FELD 280 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Administrative Contact Ina Krischek (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) Spain EU contribution € 371 000,00 Address CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA 08028 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact Alexandre Puerto Valdivieso (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KEIO UNIVERSITY Participation ended Japan EU contribution € 116 961,75 Address MITA 2-15-45 MINATO-KU 108 8345 Tokyo See on map Activity type Higher or Secondary Education Establishments Administrative Contact Toshio Suda (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KTB TUMORFORSCHUNGSGESELLSCHAFT MBH Participation ended Germany EU contribution € 385 540,24 Address BREISACHER STRASSE 117 79106 FREIBURG See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Michael Kubbutat (Dr.) Links Contact the organisation Opens in new window Total cost No data UNIVERSITATSKLINIKUM HEIDELBERG Germany EU contribution € 923 800,00 Address IM NEUENHEIMER FELD 672 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Thomas Eisenhauer (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 549 623,40 Address WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Linda Pialek (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NATIONAL UNIVERSITY OF SINGAPORE PUBLIC COMPANY LIMITED BY GUARANTEE Singapore EU contribution € 333 038,25 Address LOWER KENT RIDGE ROAD 21 119077 Singapore See on map Activity type Higher or Secondary Education Establishments Administrative Contact Raymond Soen Heok Chew (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data