Objective Although the accurate diagnosis and prevention of coronary artery disease (CAD), acute myocardial infarction (AMI) and death is a major public health issue, risk stratification for CAD with current diagnostic tools is not properly supporting clinical decision making. RiskyCAD’s overall goal is to identify novel biomarkers for asymptomatic patients in high risk of major coronary events, and develop new diagnostic tools and ‘personalized’ therapeutic strategies for this selected group of patients.Taking advantage of the latest technologies, we will look into new biomarkers for asymptomatic patients in high risk of CAD using some of the finest cohorts (WP1), identify new molecules and develop new diagnostic kits that will be further validated in additional cohorts (WP6). We will generate reprogrammed iPS cell based human models for the study of metabolic aberrations in selected individual vulnerable CAD patients (WP2). We will identify defects, e.g. in liver lipid metabolism, in high risk CAD patients (WP3) and test targeted treatments in traditional and new preclinical animal models to provide proof-of-concept level evidence (WP4, WP5). As our approach is based on well characterized patients and phenotypes, we will generate clinically applicable stratification methods that will allow targeted treatment and patient enrichment for clinical trials (WP1). Unique predictive modelling and link identification platforms including Drug Repositioning will be used to select drugs or drug combinations that will best match the patient’s biomarker profile (WP7).The final (translational) outcomes of this project will be: (i) a set of distinct biomarker test(s) for asymptomatic patients in high risk of CAD that can be ordered both by primary care physicians and specialized cardiologists from routine clinical laboratories; (ii) new CAD risk estimation models; (iii) a set of repositioned drugs ready to be exploited further for the optimal treatment of patients in high risk of CA Fields of science medical and health scienceshealth sciencespublic healthnatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsengineering and technologymedical engineeringmedical laboratory technologylaboratory samples analysis Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2012.1.2-1 - Development of technologies with a view to patient group stratification for personalised medicine applications Call for proposal FP7-HEALTH-2012-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON EU contribution € 1 135 720,00 Address SORANOU EFESIOU 4 115 27 Athina Greece See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Research Organisations Administrative Contact Dimitris Raptis (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (11) Sort alphabetically Sort by EU Contribution Expand all Collapse all ZORA BIOSCIENCES OY Finland EU contribution € 710 062,26 Address TIETOTIE 2 C 02150 Espoo See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Riikka Katainen (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Germany EU contribution € 572 235,74 Address SEMINARSTRASSE 2 69117 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Ralf Weigel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HUMMINGBIRD DIAGNOSTICS GMBH Germany EU contribution € 671 000,00 Address IM NEUENHEIMER FELD 583 69120 HEIDELBERG See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Markus Beier (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data A. PERSIDIS & SIA OE Greece EU contribution € 497 000,00 Address RODOPOLEOS STREET 34 167 77 Athina See on map Region Αττική Aττική Νότιος Τομέας Αθηνών Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Andreas Persidis (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 399 463,00 Address WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Linda Pialek (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TAMPEREEN YLIOPISTO Finland EU contribution € 545 000,00 Address Kalevantie 4 33014 TAMPERE See on map Activity type Higher or Secondary Education Establishments Administrative Contact Susanna Airila (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAT ZURICH Participation ended Switzerland EU contribution € 62 195,66 Address RAMISTRASSE 71 8006 Zurich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Ulf Landmesser (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI MILANO Italy EU contribution € 444 000,00 Address Via Festa Del Perdono 7 20122 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Administrative Contact Sergio Longo (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SYNLAB HOLDING GMBH Germany EU contribution € 72 000,00 Address GUBENER STRASSE 39 86156 AUGSBURG See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Winfried März (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GENOWAY France EU contribution € 364 620,00 Address 31 RUE SAINT JEAN DE DIEU TECHNOPARK 2 69007 Lyon See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Gaelle Le Bel (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CHARITE - UNIVERSITAETSMEDIZIN BERLIN Germany EU contribution € 518 804,34 Address Chariteplatz 1 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Administrative Contact Martina Eickmann (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data