Objective
Impaired selection of a functional and self-tolerant T cell repertoire is an underlying cause for development of immune system related disorders: immune-deficiencies and autoimmunity. However, current knowledge fails to explain how seemingly the same self-MHC/peptide complexes mediate the processes with completely different outcomes: survival versus apoptosis of T cells. In line, the nature of MHC/peptide complexes that mediate development of immune system and the influence of different antigen processing pathways on these complexes remain unresolved issues. The limitations of available technologies have left this question open. Recent advancement in the field of proteomics allows us now to precisely identify naturally occurring peptides that mediate selection of T cells. In addition, gene replacement technologies will be used to address the role of cathepsins, antigen-processing enzymes, on development of a fully functional T cell repertoire on one hand, and their effect on the quality and/or quantity of peptide epitopes displayed by cells that mediate T cell selection, on the other. The integration of proteomic methodology with in vivo experimental approach will enable us for the first time to interconnect the knowledge gained on cellular processes with direct physiological consequences in live animals. These new insights can accelerate not only discoveries related to T cell development, but are also relevant for understanding the interplay between T cells and pathogens, and can pave the way for new design and development of vaccines against infection diseases and therapies to treat autoimmunity. Thus, it directly contributes to strengthening European excellence in biomedical research. The host laboratory is one of the leading laboratories in the field of T cell biology that provides necessary expertise for successful realization of proposed project and the fellow has an outstanding track record of addressing questions related to immune-system related disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences cell biology
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
80539 Planegg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.