Objetivo Approximately 600-700 million people are infected by hookworm, primarily in sub-Saharan Africa, Southeast Asia, and Latin America. Hookworm infection ranks number one in terms of Years Lost from Disability from a neglected infectious disease, and among the top 3 in terms of lost Disability-Adjusted Life Years. HOOKVAC will be developing the first and only vaccine for human hookworm infection. A bivalent, low-cost vaccine candidate will be clinically tested for the first time in an African disease endemic population. This will be done in Gabon in a very typical setting within the Central African rainforest belt, where the incidence of hookworm infections is 30%. Inspired by preparatory research, HOOKVAC believes that it can develop the vaccine with at least 80% efficacy against moderate and heavy hookworm infections that lasts at five years after immunization. Cost effectiveness modelling has shown that such a vaccine will significantly improve the efficacy of the current mass drug administration programs. HOOKVAC will play a crucial role in advancing toward large scale efficacy studies in African endemic areas. Via a program of 48 months with 6 work packages, HOOKVAC will address 4 main objectives: (1) establish safety and immunogenicity of the vaccine candidate in an endemic population (2) improve the manufacturing process (3) provide clinical proof of concept (4) improve accessibility of the vaccine in endemic areas. The involvement of European SMEs in the project is a critical component to advancing a successful vaccine, and an integral part of adding private sector know-how and scientific expertise to the project. This will inspire other European SMEs to become more involved in public/private vaccine product development for neglected infectious diseases. By doing so, HOOKVAC will fuel a follow-up programme for further development of the vaccine towards into a licensed product. Ámbito científico engineering and technologymechanical engineeringmanufacturing engineeringmedical and health sciencesbasic medicineimmunologyimmunisationmedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programa(s) FP7-HEALTH - Specific Programme "Cooperation": Health Tema(s) HEALTH.2013.2.3.0-1 - Innovation in vaccines Convocatoria de propuestas FP7-HEALTH-2013-INNOVATION-1 Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP - Small or medium-scale focused research project Coordinador ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Aportación de la UE € 1 773 844,00 Dirección MEIBERGDREEF 15 1105AZ Amsterdam Países Bajos Ver en el mapa Región West-Nederland Noord-Holland Groot-Amsterdam Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Friso Janssen (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (8) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo ALBERT B. SABIN VACCINE INSTITUTE INC Estados Unidos Aportación de la UE € 420 816,00 Dirección PENNSYLVANIA AV NW SUITE 7100 2000 20006 WASHINGTON DC Ver en el mapa Tipo de actividad Research Organisations Contacto administrativo Brian Davis (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos EBERHARD KARLS UNIVERSITAET TUEBINGEN Alemania Aportación de la UE € 47 934,00 Dirección GESCHWISTER-SCHOLL-PLATZ 72074 Tuebingen Ver en el mapa Región Baden-Württemberg Tübingen Tübingen, Landkreis Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Ilka Westermann (Mrs.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Centre de Recherches Medicales de Lambaréné Gabón Aportación de la UE € 994 800,00 Dirección NA 118 Lambaréné Ver en el mapa Tipo de actividad Research Organisations Contacto administrativo Ayola Akim Adegnika (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Q-BIOLOGICALS NV Bélgica Aportación de la UE € 1 589 690,00 Dirección TECHNOLOGIEPARK 4 9052 Gent Ver en el mapa Región Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Annie Van Broekhoven (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Pharmidex Pharmaceutical Services Limited Reino Unido Aportación de la UE € 352 291,00 Dirección HANOVER STREET 14 FLOOR 3 W1S 1RR London Ver en el mapa Región London Inner London — West Westminster Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Mo Alavijeh (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos ACADEMISCH ZIEKENHUIS LEIDEN Países Bajos Aportación de la UE € 400 230,00 Dirección ALBINUSDREEF 2 2333 ZA Leiden Ver en el mapa Región West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Maria Yazdanbakhsh (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos BAYLOR COLLEGE OF MEDICINE Estados Unidos Aportación de la UE € 198 631,00 Dirección ONE BAYLOR PLAZA T119 77030 Houston Tx Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Leanne B. Scott (Dr.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos GEORGE WASHINGTON UNIVERSITY CORPORATION Estados Unidos Aportación de la UE € 221 747,00 Dirección EYE STREET NW 2121 20052 Washington Dc Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Jackie Bendall (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos