CORDIS
EU research results

CORDIS

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Multi-dimensional omics approach to stratification of patients with low back pain

Project information

Grant agreement ID: 602736

Status

Closed project

  • Start date

    1 September 2013

  • End date

    31 August 2018

Funded under:

FP7-HEALTH

  • Overall budget:

    € 8 576 693,56

  • EU contribution

    € 5 998 886

Coordinated by:

UNIVERSITA DEGLI STUDI DI PARMA

Italy

Objective

"Pain-OMICS is a multidisciplinary consortium of leading clinical, academic and SME researchers in pain and different omics technologies. Genome-wide association studies identified a number of loci associated with pain, but the level of knowledge about underlying mechanisms of different pain syndromes as well as individual variation in the disease course remains inadequate. Pain-OMICS will capitalise on its existing high quality clinical, genetic, biochemical and pharmacological data and biological samples on over 5000 well characterised patients with low-back pain (LBP) and controls available to our EU and US clinical partners. We will exploit novel technological approaches made available through the expertise and global leading position of our analytical partners. These comprise cutting edge genomic, epigenomic, glycomic, and activomic approaches which reflect signal transduction and membrane dynamics. We believe that the inclusion of these complementary analyses will elucidate pathways through which acute LBP fails to resolve and becomes chronic LBP. In addition, these approaches will reveal pathways and biomarkers of chronic pain through which individual differences affects symptoms and response to therapy. Participation of leading clinics on both sides of the Atlantic will enable replication of all finding in at least three independent large cohorts, as well as in prospective study and a large twin cohort. A complex systems biology approach will be used to integrate, interrogate and understand this multidimensional dataset in order to achieve the aims of identifying novel diagnostic and prognostic biomarkers as well as new targets for therapeutic intervention. The track record of achievement of our partners coupled to participation of research-intensive SMEs is a strong indication that the ambitious work programme will be achieved and provides a framework for rapid translation of research discoveries into solutions for the benefit of large numbers of patients."
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Coordinator

UNIVERSITA DEGLI STUDI DI PARMA

Address

Via Universita 12
43100 Parma

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 156 980

Administrative Contact

Massimo Allegri (Prof.)

Participants (10)

ZIEKENHUIS OOST-LIMBURG AUTONOME VERZORGINGSINSTELLING

Belgium

EU Contribution

€ 322 400

"SPECIJALNA BOLNICA ZA ORTOPEDIJU, KIRURGIJU, NEUROLOGIJU I FIZIKALNU MEDICINU I REHABILITACIJU SVETA KATARINA USTANOVA"

Croatia

EU Contribution

€ 669 300

FONDAZIONE IRCCS POLICLINICO SAN MATTEO

Italy

EU Contribution

€ 320 000

KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 524 124

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany

EU Contribution

€ 750 364

YURII AULCHENKO

Netherlands

EU Contribution

€ 324 498

GENOS DOO ZA VJESTACENJE I ANALIZU

Croatia

EU Contribution

€ 990 300

IP RESEARCH CONSULTING SASU

France

EU Contribution

€ 359 900

THE CENTER FOR CLINICAL RESEARCH LLC

United States

EU Contribution

€ 581 020

Edith Cowan University

Australia

Project information

Grant agreement ID: 602736

Status

Closed project

  • Start date

    1 September 2013

  • End date

    31 August 2018

Funded under:

FP7-HEALTH

  • Overall budget:

    € 8 576 693,56

  • EU contribution

    € 5 998 886

Coordinated by:

UNIVERSITA DEGLI STUDI DI PARMA

Italy