Skip to main content

Multi-dimensional omics approach to stratification of patients with low back pain

Objective

"Pain-OMICS is a multidisciplinary consortium of leading clinical, academic and SME researchers in pain and different omics technologies. Genome-wide association studies identified a number of loci associated with pain, but the level of knowledge about underlying mechanisms of different pain syndromes as well as individual variation in the disease course remains inadequate. Pain-OMICS will capitalise on its existing high quality clinical, genetic, biochemical and pharmacological data and biological samples on over 5000 well characterised patients with low-back pain (LBP) and controls available to our EU and US clinical partners. We will exploit novel technological approaches made available through the expertise and global leading position of our analytical partners. These comprise cutting edge genomic, epigenomic, glycomic, and activomic approaches which reflect signal transduction and membrane dynamics. We believe that the inclusion of these complementary analyses will elucidate pathways through which acute LBP fails to resolve and becomes chronic LBP. In addition, these approaches will reveal pathways and biomarkers of chronic pain through which individual differences affects symptoms and response to therapy. Participation of leading clinics on both sides of the Atlantic will enable replication of all finding in at least three independent large cohorts, as well as in prospective study and a large twin cohort. A complex systems biology approach will be used to integrate, interrogate and understand this multidimensional dataset in order to achieve the aims of identifying novel diagnostic and prognostic biomarkers as well as new targets for therapeutic intervention. The track record of achievement of our partners coupled to participation of research-intensive SMEs is a strong indication that the ambitious work programme will be achieved and provides a framework for rapid translation of research discoveries into solutions for the benefit of large numbers of patients."

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITA DEGLI STUDI DI PARMA
Address
Via Universita 12
43100 Parma
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 156 980
Administrative Contact
Massimo Allegri (Prof.)

Participants (10)

ZIEKENHUIS OOST-LIMBURG AUTONOME VERZORGINGSINSTELLING
Belgium
EU contribution
€ 322 400
Address
Schiepse Bos
3600 Genk
Activity type
Research Organisations
Administrative Contact
Joke Vanlangenaeker (Mrs.)
"SPECIJALNA BOLNICA ZA ORTOPEDIJU, KIRURGIJU, NEUROLOGIJU I FIZIKALNU MEDICINU I REHABILITACIJU SVETA KATARINA USTANOVA"
Croatia
EU contribution
€ 669 300
Address
Bracak 8
49210 Zabok
Activity type
Research Organisations
Administrative Contact
Dragan Primorac (Prof.)
FONDAZIONE IRCCS POLICLINICO SAN MATTEO
Italy
EU contribution
€ 320 000
Address
Viale Golgi 19
27100 Pavia
Activity type
Research Organisations
Administrative Contact
Franco Marazza (Mr.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 524 124
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Mr.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 750 364
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
Administrative Contact
Juergen Ertel (Dr.)
YURII AULCHENKO
Netherlands
EU contribution
€ 324 498
Address
Tweede Hunzestraat 9 A
3067 EV Rotterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Yury Aulchenko (Dr.)
GENOS DOO ZA VJESTACENJE I ANALIZU
Croatia
EU contribution
€ 990 300
Address
Vatrogasna 112
31000 Osijek
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Cizmesija Ivana (Mrs.)
IP RESEARCH CONSULTING SASU
France
EU contribution
€ 359 900
Address
Quai Des Deux Ponts 31
93160 Noisy Le Grand
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Iain Pemberton (Dr.)
THE CENTER FOR CLINICAL RESEARCH LLC
United States
EU contribution
€ 581 020
Address
Kimel Park Drive 145 Suite 330
27103 Winston Salem
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Leonardo Kapural (Dr.)
Edith Cowan University
Australia
Address
Joondalup Drive 270
6027 Joondalup
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda Penny (Ms.)